CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugs
Pulmonary fibrosis is an interstitial lung disease characterized by chronic progressive fibrosis. It is associated with fibrocyte proliferation and collagen deposition, leading to severe, irreversible lung function decline. Despite extensive research, the diagnosis and treatment of pulmonary fibrosi...
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| Format: | Article |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1562892/full |
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| author | Xiaobo Sun Xinwen Zhang Yuhan He Xueting Du Qian Cai Zhihong Liu |
| author_facet | Xiaobo Sun Xinwen Zhang Yuhan He Xueting Du Qian Cai Zhihong Liu |
| author_sort | Xiaobo Sun |
| collection | DOAJ |
| description | Pulmonary fibrosis is an interstitial lung disease characterized by chronic progressive fibrosis. It is associated with fibrocyte proliferation and collagen deposition, leading to severe, irreversible lung function decline. Despite extensive research, the diagnosis and treatment of pulmonary fibrosis are complicated and have no effective treatment. During the formation of pulmonary fibrosis, immune dysregulation by inflammatory cell infiltration is the key driver of pulmonary fibrosis. Recently, single-cell sequencing analysis of silicosis mice showed that various cells in the alveolar immune microenvironment are involved in forming pulmonary fibrosis, such as macrophages, fibroblasts, epithelial cells, etc. Among them, T cell subpopulations in silicosis mice were significantly activated, indicating that T lymphocyte subsets play an essential role in the process of pulmonary fibrosis. More and more pulmonary clinical studies show that T lymphocytes in the lung immune microenvironment play an important and multifaceted role. This article summarizes the role of CD4+T cells and CD8+T cells in pulmonary fibrosis. This article provides some new insight into the potential therapy target that can delay the process of pulmonary fibrosis by regulating the proportions of different subpopulations of T lymphocytes and some related signaling pathways. |
| format | Article |
| id | doaj-art-8a28dccd212b41b69a4439705161a0e8 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8a28dccd212b41b69a4439705161a0e82025-08-20T02:58:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15628921562892CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugsXiaobo Sun0Xinwen Zhang1Yuhan He2Xueting Du3Qian Cai4Zhihong Liu5Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, ChinaPathogenic Microbiology Laboratory, Yinchuan Center for Disease Control and Prevention, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, ChinaKey Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, ChinaPulmonary fibrosis is an interstitial lung disease characterized by chronic progressive fibrosis. It is associated with fibrocyte proliferation and collagen deposition, leading to severe, irreversible lung function decline. Despite extensive research, the diagnosis and treatment of pulmonary fibrosis are complicated and have no effective treatment. During the formation of pulmonary fibrosis, immune dysregulation by inflammatory cell infiltration is the key driver of pulmonary fibrosis. Recently, single-cell sequencing analysis of silicosis mice showed that various cells in the alveolar immune microenvironment are involved in forming pulmonary fibrosis, such as macrophages, fibroblasts, epithelial cells, etc. Among them, T cell subpopulations in silicosis mice were significantly activated, indicating that T lymphocyte subsets play an essential role in the process of pulmonary fibrosis. More and more pulmonary clinical studies show that T lymphocytes in the lung immune microenvironment play an important and multifaceted role. This article summarizes the role of CD4+T cells and CD8+T cells in pulmonary fibrosis. This article provides some new insight into the potential therapy target that can delay the process of pulmonary fibrosis by regulating the proportions of different subpopulations of T lymphocytes and some related signaling pathways.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1562892/fullCD4 + T cellsCD8 + T cellsinflammationpulmonary fibrosisdrug and target |
| spellingShingle | Xiaobo Sun Xinwen Zhang Yuhan He Xueting Du Qian Cai Zhihong Liu CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugs Frontiers in Immunology CD4 + T cells CD8 + T cells inflammation pulmonary fibrosis drug and target |
| title | CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugs |
| title_full | CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugs |
| title_fullStr | CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugs |
| title_full_unstemmed | CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugs |
| title_short | CD4+T and CD8+T cells profile in lung inflammation and fibrosis: targets and potential therapeutic drugs |
| title_sort | cd4 t and cd8 t cells profile in lung inflammation and fibrosis targets and potential therapeutic drugs |
| topic | CD4 + T cells CD8 + T cells inflammation pulmonary fibrosis drug and target |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1562892/full |
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