S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children

The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H pylori-infected...

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Main Authors: Steven T Leach, Hazel M Mitchell, Carolyn L Geczy, Philip M Sherman, Andrew S Day
Format: Article
Language:English
Published: Wiley 2008-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2008/308942
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author Steven T Leach
Hazel M Mitchell
Carolyn L Geczy
Philip M Sherman
Andrew S Day
author_facet Steven T Leach
Hazel M Mitchell
Carolyn L Geczy
Philip M Sherman
Andrew S Day
author_sort Steven T Leach
collection DOAJ
description The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H pylori-infected mucosa. This expression correlated with the severity of gastritis (r=0.9422, P<0.05). S100 calgranulins may be involved in bacterial-induced gastritis and may limit bacterial growth.
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institution Kabale University
issn 0835-7900
language English
publishDate 2008-01-01
publisher Wiley
record_format Article
series Canadian Journal of Gastroenterology
spelling doaj-art-8a28a1c1b23b4cc4868e4d448b8770d42025-02-03T01:00:03ZengWileyCanadian Journal of Gastroenterology0835-79002008-01-0122546146410.1155/2008/308942S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected ChildrenSteven T Leach0Hazel M Mitchell1Carolyn L Geczy2Philip M Sherman3Andrew S Day4School of Women’s and Children’s Health, University of New South Wales, Sydney, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, AustraliaInflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, Sydney, AustraliaHospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaSchool of Women’s and Children’s Health, University of New South Wales, Sydney, AustraliaThe expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H pylori-infected mucosa. This expression correlated with the severity of gastritis (r=0.9422, P<0.05). S100 calgranulins may be involved in bacterial-induced gastritis and may limit bacterial growth.http://dx.doi.org/10.1155/2008/308942
spellingShingle Steven T Leach
Hazel M Mitchell
Carolyn L Geczy
Philip M Sherman
Andrew S Day
S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children
Canadian Journal of Gastroenterology
title S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children
title_full S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children
title_fullStr S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children
title_full_unstemmed S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children
title_short S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa of Helicobacter Pylori-Infected Children
title_sort s100 calgranulin proteins s100a8 s100a9 and s100a12 are expressed in the inflamed gastric mucosa of helicobacter pylori infected children
url http://dx.doi.org/10.1155/2008/308942
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