Female infertility from oocyte maturation arrest: assembling the genetic puzzle
Abstract Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence...
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| Format: | Article |
| Language: | English |
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Springer Nature
2023-04-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202317729 |
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| author | Xinbao Ding John C Schimenti |
| author_facet | Xinbao Ding John C Schimenti |
| author_sort | Xinbao Ding |
| collection | DOAJ |
| description | Abstract Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants in a gene called PABPC1L, which is essential for translation of maternal mRNAs. By conducting a series of in vitro and in vivo experiments, they demonstrated certain variants as being causal for OMA, confirming a conserved requirement for PABPC1L in human oocyte maturation. This study offers a promising therapeutic target for treating OMA patients. |
| format | Article |
| id | doaj-art-8a1cc6004a054f28a59a4d2175a9c14b |
| institution | DOAJ |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-8a1cc6004a054f28a59a4d2175a9c14b2025-08-20T03:05:53ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842023-04-011561310.15252/emmm.202317729Female infertility from oocyte maturation arrest: assembling the genetic puzzleXinbao Ding0John C Schimenti1Department of Biomedical Sciences, College of Veterinary Medicine, Cornell UniversityDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell UniversityAbstract Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al identify infertile women bearing novel DNA sequence variants in a gene called PABPC1L, which is essential for translation of maternal mRNAs. By conducting a series of in vitro and in vivo experiments, they demonstrated certain variants as being causal for OMA, confirming a conserved requirement for PABPC1L in human oocyte maturation. This study offers a promising therapeutic target for treating OMA patients.https://doi.org/10.15252/emmm.202317729 |
| spellingShingle | Xinbao Ding John C Schimenti Female infertility from oocyte maturation arrest: assembling the genetic puzzle EMBO Molecular Medicine |
| title | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
| title_full | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
| title_fullStr | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
| title_full_unstemmed | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
| title_short | Female infertility from oocyte maturation arrest: assembling the genetic puzzle |
| title_sort | female infertility from oocyte maturation arrest assembling the genetic puzzle |
| url | https://doi.org/10.15252/emmm.202317729 |
| work_keys_str_mv | AT xinbaoding femaleinfertilityfromoocytematurationarrestassemblingthegeneticpuzzle AT johncschimenti femaleinfertilityfromoocytematurationarrestassemblingthegeneticpuzzle |