Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment
Abstract Hydrogen therapy has shown new potential in cancer treatment, particularly in high‐pressure and hypoxic areas, where it demonstrates the ability to alter the tumor microenvironment and regulate tumor metabolism. Hydrogen disrupts the mitochondrial function of cancer cells, interferes with t...
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202413519 |
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| author | Rui Zhang Qian Wang Junjie Pan Jun Du Han Yang Bingfeng Wang Yuhao Li Yuqing Miao Xumin Hou Jingxiang Wu Qing Miao |
| author_facet | Rui Zhang Qian Wang Junjie Pan Jun Du Han Yang Bingfeng Wang Yuhao Li Yuqing Miao Xumin Hou Jingxiang Wu Qing Miao |
| author_sort | Rui Zhang |
| collection | DOAJ |
| description | Abstract Hydrogen therapy has shown new potential in cancer treatment, particularly in high‐pressure and hypoxic areas, where it demonstrates the ability to alter the tumor microenvironment and regulate tumor metabolism. Hydrogen disrupts the mitochondrial function of cancer cells, interferes with their energy metabolism, and ultimately leads to energy depletion and apoptosis. In this study, a sonocatalyst (BPM), is designed to generate hydrogen and oxygen in situ within tumors, further enhancing the therapeutic efficacy. The mesocrystalline structure of BPM, composed of bismuth fluoride, polyoxometalates, and molybdenum carbide, significantly improves charge separation and electron transfer efficiency under ultrasound irradiation, resulting in an efficient water‐splitting reaction. By simultaneously generating hydrogen and oxygen within the tumor microenvironment and depleting glutathione, BPM effectively triggers oxidative stress and alleviates hypoxia, thereby disrupting mitochondrial function and inhibiting energy metabolism in cancer cells. Additionally, BPM enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, and polarizing macrophages toward the M1 phenotype, reversing the immunosuppressive state of the tumor microenvironment. The results indicate that BPM holds potential for gas‐immunotherapy combination treatments, offering a multifunctional strategy to improve cancer therapy outcomes. |
| format | Article |
| id | doaj-art-8a19dd9822e843b09c8bc7c9d2104328 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-8a19dd9822e843b09c8bc7c9d21043282025-08-20T01:51:39ZengWileyAdvanced Science2198-38442025-04-011213n/an/a10.1002/advs.202413519Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer TreatmentRui Zhang0Qian Wang1Junjie Pan2Jun Du3Han Yang4Bingfeng Wang5Yuhao Li6Yuqing Miao7Xumin Hou8Jingxiang Wu9Qing Miao10Department of Anesthesiology Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 ChinaInstitute of Bismuth Science School of Materials and Chemistry Shanghai Collaborative Innovation Center of Energy Therapy for Tumors University of Shanghai for Science and Technology Shanghai 200093 ChinaInstitute of Bismuth Science School of Materials and Chemistry Shanghai Collaborative Innovation Center of Energy Therapy for Tumors University of Shanghai for Science and Technology Shanghai 200093 ChinaInstitute of Bismuth Science School of Materials and Chemistry Shanghai Collaborative Innovation Center of Energy Therapy for Tumors University of Shanghai for Science and Technology Shanghai 200093 ChinaInstitute of Bismuth Science School of Materials and Chemistry Shanghai Collaborative Innovation Center of Energy Therapy for Tumors University of Shanghai for Science and Technology Shanghai 200093 ChinaCollege of Materials and Energy South China Agricultural University Guangzhou 510631 ChinaInstitute of Bismuth Science School of Materials and Chemistry Shanghai Collaborative Innovation Center of Energy Therapy for Tumors University of Shanghai for Science and Technology Shanghai 200093 ChinaInstitute of Bismuth Science School of Materials and Chemistry Shanghai Collaborative Innovation Center of Energy Therapy for Tumors University of Shanghai for Science and Technology Shanghai 200093 ChinaDepartment of Anesthesiology Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 ChinaDepartment of Anesthesiology Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 ChinaDepartment of Anesthesiology Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 ChinaAbstract Hydrogen therapy has shown new potential in cancer treatment, particularly in high‐pressure and hypoxic areas, where it demonstrates the ability to alter the tumor microenvironment and regulate tumor metabolism. Hydrogen disrupts the mitochondrial function of cancer cells, interferes with their energy metabolism, and ultimately leads to energy depletion and apoptosis. In this study, a sonocatalyst (BPM), is designed to generate hydrogen and oxygen in situ within tumors, further enhancing the therapeutic efficacy. The mesocrystalline structure of BPM, composed of bismuth fluoride, polyoxometalates, and molybdenum carbide, significantly improves charge separation and electron transfer efficiency under ultrasound irradiation, resulting in an efficient water‐splitting reaction. By simultaneously generating hydrogen and oxygen within the tumor microenvironment and depleting glutathione, BPM effectively triggers oxidative stress and alleviates hypoxia, thereby disrupting mitochondrial function and inhibiting energy metabolism in cancer cells. Additionally, BPM enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, and polarizing macrophages toward the M1 phenotype, reversing the immunosuppressive state of the tumor microenvironment. The results indicate that BPM holds potential for gas‐immunotherapy combination treatments, offering a multifunctional strategy to improve cancer therapy outcomes.https://doi.org/10.1002/advs.202413519gas therapyglutathione consumptionimmune activationSchottky junctionwater splitting |
| spellingShingle | Rui Zhang Qian Wang Junjie Pan Jun Du Han Yang Bingfeng Wang Yuhao Li Yuqing Miao Xumin Hou Jingxiang Wu Qing Miao Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment Advanced Science gas therapy glutathione consumption immune activation Schottky junction water splitting |
| title | Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment |
| title_full | Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment |
| title_fullStr | Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment |
| title_full_unstemmed | Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment |
| title_short | Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment |
| title_sort | ternary schottky junction for sonocatalytic water splitting in gas immunotherapy mediated cancer treatment |
| topic | gas therapy glutathione consumption immune activation Schottky junction water splitting |
| url | https://doi.org/10.1002/advs.202413519 |
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