Modeling combinatorial regulation from single-cell multi-omics provides regulatory units underpinning cell type landscape using cRegulon

Modeling combinatorial regulation from single-cell multi-omics provides regulatory units underpinning cell type landscape using cRegulon

Abstract Advances in single-cell technology enable large-scale generation of omics data, promising for clarifying gene regulatory networks governing different cell type/states. Nonetheless, prevailing methods fail to account for universal and reusable regulatory modules in GRNs, which are fundamenta...

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Bibliographic Details
Main Authors: Zhanying Feng, Xi Chen, Zhana Duren, Jingxue Xin, Hao Miao, Qiuyue Yuan, Yong Wang, Wing Hung Wong
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03680-w
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