Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?
Infection with M. tuberculosis remains one of the most common infections in the world. The outcome of the infection depends on host ability to mount effective protection and balance inflammatory responses. Neutrophils are innate immune cells implicated in both processes. Accordingly, during M. tuber...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8619307 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554163776520192 |
|---|---|
| author | Irina V. Lyadova |
| author_facet | Irina V. Lyadova |
| author_sort | Irina V. Lyadova |
| collection | DOAJ |
| description | Infection with M. tuberculosis remains one of the most common infections in the world. The outcome of the infection depends on host ability to mount effective protection and balance inflammatory responses. Neutrophils are innate immune cells implicated in both processes. Accordingly, during M. tuberculosis infection, they play a dual role. Particularly, they contribute to the generation of effector T cells, participate in the formation of granuloma, and are directly involved in tissue necrosis, destruction, and infection dissemination. Neutrophils have a high bactericidal potential. However, data on their ability to eliminate M. tuberculosis are controversial, and the results of neutrophil depletion experiments are not uniform. Thus, the overall roles of neutrophils during M. tuberculosis infection and factors that determine these roles are not fully understood. This review analyzes data on neutrophil defensive and pathological functions during tuberculosis and considers hypotheses explaining the dualism of neutrophils during M. tuberculosis infection and tuberculosis disease. |
| format | Article |
| id | doaj-art-8a1783e3477f476e9cc12211f669c30d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8a1783e3477f476e9cc12211f669c30d2025-02-03T05:52:18ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/86193078619307Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?Irina V. Lyadova0Immunology Department, Central Tuberculosis Research Institute, Yauza Alley 2, Moscow 107564, RussiaInfection with M. tuberculosis remains one of the most common infections in the world. The outcome of the infection depends on host ability to mount effective protection and balance inflammatory responses. Neutrophils are innate immune cells implicated in both processes. Accordingly, during M. tuberculosis infection, they play a dual role. Particularly, they contribute to the generation of effector T cells, participate in the formation of granuloma, and are directly involved in tissue necrosis, destruction, and infection dissemination. Neutrophils have a high bactericidal potential. However, data on their ability to eliminate M. tuberculosis are controversial, and the results of neutrophil depletion experiments are not uniform. Thus, the overall roles of neutrophils during M. tuberculosis infection and factors that determine these roles are not fully understood. This review analyzes data on neutrophil defensive and pathological functions during tuberculosis and considers hypotheses explaining the dualism of neutrophils during M. tuberculosis infection and tuberculosis disease.http://dx.doi.org/10.1155/2017/8619307 |
| spellingShingle | Irina V. Lyadova Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? Mediators of Inflammation |
| title | Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? |
| title_full | Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? |
| title_fullStr | Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? |
| title_full_unstemmed | Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? |
| title_short | Neutrophils in Tuberculosis: Heterogeneity Shapes the Way? |
| title_sort | neutrophils in tuberculosis heterogeneity shapes the way |
| url | http://dx.doi.org/10.1155/2017/8619307 |
| work_keys_str_mv | AT irinavlyadova neutrophilsintuberculosisheterogeneityshapestheway |