Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs
Carbon nanotubes (CNTs) have wide range of usage in industrial applications due to their exceptional characteristics. There have been some concerns regarding their possible negative health impacts, especially in working environment. Present study highlights the effects of dose, exposure duration, an...
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Elsevier
2025-07-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625003431 |
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| author | Iqra Nasim Rab Nawaz Nadia Ghani Mohammad Raish Muhammad Atif Irshad Maryam Nasim Ali Irfan Samina Aslam Bakar Bin Khatab Abbasi Yousef A. Bin Jardan |
| author_facet | Iqra Nasim Rab Nawaz Nadia Ghani Mohammad Raish Muhammad Atif Irshad Maryam Nasim Ali Irfan Samina Aslam Bakar Bin Khatab Abbasi Yousef A. Bin Jardan |
| author_sort | Iqra Nasim |
| collection | DOAJ |
| description | Carbon nanotubes (CNTs) have wide range of usage in industrial applications due to their exceptional characteristics. There have been some concerns regarding their possible negative health impacts, especially in working environment. Present study highlights the effects of dose, exposure duration, and particle size of multi-walled carbon nanotube nanoparticles (MWCNT-NPs) on the histopathology and pulmonary oxidative stress in Swiss albino mice. Experiments were carried out using twenty mice, which were divided into six groups. Two groups were exposed to MWCNT-NPs through oral gavage for seven days at doses of 0.45 μg and 0.90 μg, respectively. A third group served as the control and received only distilled water for the same seven-day period. Other two groups were treated with MWCNT-NPs for fourteen days at the same dosages of 0.45 μg and 0.90 μg. The final group served as the fourteen-day control and received distilled water only. Glutathione (GSH) and glutathione disulfide (GSSG), the two main oxidative stress indicators were evaluated in the study. Comparing the experimental group to the control group, the results showed a substantial decline in GSH levels and an increase in GSSG concentrations at the same time. The histopathology indicated that MWCNT-NPs had a major effect on lung health, including the possibility of Acute Lung Injury (ALI), disruption of respiratory function, pulmonary edema, and enhanced permeability. The redox potential was estimated using the Nernst equation to understand the redox status. The negative value of results indicated an oxidative imbalance. These findings showed that MWCNT-NPs induced pulmonary oxidative stress in response to short term exposure, as indicated by alterations in the levels of GSH and GSSG and the negative redox potential. The study emphasizes the importance of assessing oxidative stress in evaluations of nanomaterial toxicity and provides crucial insights into the respiratory effects of exposure to multi-walled carbon nanotube nanoparticles. |
| format | Article |
| id | doaj-art-8a16360f4f544d4e926cb90e4fa8ef2c |
| institution | DOAJ |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-8a16360f4f544d4e926cb90e4fa8ef2c2025-08-20T03:02:36ZengElsevierResults in Chemistry2211-71562025-07-011610236010.1016/j.rechem.2025.102360Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPsIqra Nasim0Rab Nawaz1Nadia Ghani2Mohammad Raish3Muhammad Atif Irshad4Maryam Nasim5Ali Irfan6Samina Aslam7Bakar Bin Khatab Abbasi8Yousef A. Bin Jardan9Department of Environmental Science, Lahore College for Women University, Lahore 54000, Pakistan; Department of Environmental Sciences, The University of Lahore, Lahore 54000, PakistanDepartment of Environmental Sciences, The University of Lahore, Lahore 54000, Pakistan; Faculty of Engineering and Quantity Surveying, INTI International University, 71800, Nilai, Negeri Sembilan, MalaysiaDepartment of Environmental Science, Lahore College for Women University, Lahore 54000, Pakistan; Corresponding authors.Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Environmental Sciences, The University of Lahore, Lahore 54000, PakistanDepartment of Allied Health Sciences, Riphah International University, Islamabad, PakistanDepartment of Chemistry, Government College University Faisalabad, Faisalabad-38000, Pakistan; Corresponding authors.Department of Chemistry, The Women University Multan, Multan-60000, PakistanDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USADepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; Corresponding authors.Carbon nanotubes (CNTs) have wide range of usage in industrial applications due to their exceptional characteristics. There have been some concerns regarding their possible negative health impacts, especially in working environment. Present study highlights the effects of dose, exposure duration, and particle size of multi-walled carbon nanotube nanoparticles (MWCNT-NPs) on the histopathology and pulmonary oxidative stress in Swiss albino mice. Experiments were carried out using twenty mice, which were divided into six groups. Two groups were exposed to MWCNT-NPs through oral gavage for seven days at doses of 0.45 μg and 0.90 μg, respectively. A third group served as the control and received only distilled water for the same seven-day period. Other two groups were treated with MWCNT-NPs for fourteen days at the same dosages of 0.45 μg and 0.90 μg. The final group served as the fourteen-day control and received distilled water only. Glutathione (GSH) and glutathione disulfide (GSSG), the two main oxidative stress indicators were evaluated in the study. Comparing the experimental group to the control group, the results showed a substantial decline in GSH levels and an increase in GSSG concentrations at the same time. The histopathology indicated that MWCNT-NPs had a major effect on lung health, including the possibility of Acute Lung Injury (ALI), disruption of respiratory function, pulmonary edema, and enhanced permeability. The redox potential was estimated using the Nernst equation to understand the redox status. The negative value of results indicated an oxidative imbalance. These findings showed that MWCNT-NPs induced pulmonary oxidative stress in response to short term exposure, as indicated by alterations in the levels of GSH and GSSG and the negative redox potential. The study emphasizes the importance of assessing oxidative stress in evaluations of nanomaterial toxicity and provides crucial insights into the respiratory effects of exposure to multi-walled carbon nanotube nanoparticles.http://www.sciencedirect.com/science/article/pii/S2211715625003431Multi-walled carbon nanotube nanoparticles (MWCNT-NPs)PulmonaryOxidative stressHistopathological changesOxidized glutathioneGlutathione disulfide |
| spellingShingle | Iqra Nasim Rab Nawaz Nadia Ghani Mohammad Raish Muhammad Atif Irshad Maryam Nasim Ali Irfan Samina Aslam Bakar Bin Khatab Abbasi Yousef A. Bin Jardan Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs Results in Chemistry Multi-walled carbon nanotube nanoparticles (MWCNT-NPs) Pulmonary Oxidative stress Histopathological changes Oxidized glutathione Glutathione disulfide |
| title | Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs |
| title_full | Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs |
| title_fullStr | Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs |
| title_full_unstemmed | Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs |
| title_short | Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs |
| title_sort | assessing the pulmonary oxidative stress and histopathological changes in swiss albino mice following exposure to mwcnt nps |
| topic | Multi-walled carbon nanotube nanoparticles (MWCNT-NPs) Pulmonary Oxidative stress Histopathological changes Oxidized glutathione Glutathione disulfide |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625003431 |
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