Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.
The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (...
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Public Library of Science (PLoS)
2011-01-01
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| author | Galina Lurie Lynne R Wilkens Pamela J Thompson Yurii B Shvetsov Rayna K Matsuno Michael E Carney Rachel T Palmieri Anna H Wu Malcolm C Pike Celeste L Pearce Usha Menon Aleksandra Gentry-Maharaj Simon A Gayther Susan J Ramus Alice S Whittemore Valerie McGuire Weiva Sieh Paul D P Pharoah Honglin Song Jacek Gronwald Anna Jakubowska Cezary Cybulski Jan Lubinski Joellen M Schildkraut Andrew Berchuck Susanne Krüger Kjær Estrid Høgdall Peter A Fasching Matthias W Beckmann Arif B Ekici Alexander Hein Georgia Chenevix-Trench Penelope M Webb Jonathan Beesley Australian Ovarian Cancer Study Group Australian Cancer Study Group Marc T Goodman Ovarian Cancer Association Consortium |
| author_facet | Galina Lurie Lynne R Wilkens Pamela J Thompson Yurii B Shvetsov Rayna K Matsuno Michael E Carney Rachel T Palmieri Anna H Wu Malcolm C Pike Celeste L Pearce Usha Menon Aleksandra Gentry-Maharaj Simon A Gayther Susan J Ramus Alice S Whittemore Valerie McGuire Weiva Sieh Paul D P Pharoah Honglin Song Jacek Gronwald Anna Jakubowska Cezary Cybulski Jan Lubinski Joellen M Schildkraut Andrew Berchuck Susanne Krüger Kjær Estrid Høgdall Peter A Fasching Matthias W Beckmann Arif B Ekici Alexander Hein Georgia Chenevix-Trench Penelope M Webb Jonathan Beesley Australian Ovarian Cancer Study Group Australian Cancer Study Group Marc T Goodman Ovarian Cancer Association Consortium |
| author_sort | Galina Lurie |
| collection | DOAJ |
| description | The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women. |
| format | Article |
| id | doaj-art-8a0fbb5a474744b89b18f2416069296b |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-8a0fbb5a474744b89b18f2416069296b2025-08-20T03:46:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0166e2070310.1371/journal.pone.0020703Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.Galina LurieLynne R WilkensPamela J ThompsonYurii B ShvetsovRayna K MatsunoMichael E CarneyRachel T PalmieriAnna H WuMalcolm C PikeCeleste L PearceUsha MenonAleksandra Gentry-MaharajSimon A GaytherSusan J RamusAlice S WhittemoreValerie McGuireWeiva SiehPaul D P PharoahHonglin SongJacek GronwaldAnna JakubowskaCezary CybulskiJan LubinskiJoellen M SchildkrautAndrew BerchuckSusanne Krüger KjærEstrid HøgdallPeter A FaschingMatthias W BeckmannArif B EkiciAlexander HeinGeorgia Chenevix-TrenchPenelope M WebbJonathan BeesleyAustralian Ovarian Cancer Study GroupAustralian Cancer Study GroupMarc T GoodmanOvarian Cancer Association ConsortiumThe association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020703&type=printable |
| spellingShingle | Galina Lurie Lynne R Wilkens Pamela J Thompson Yurii B Shvetsov Rayna K Matsuno Michael E Carney Rachel T Palmieri Anna H Wu Malcolm C Pike Celeste L Pearce Usha Menon Aleksandra Gentry-Maharaj Simon A Gayther Susan J Ramus Alice S Whittemore Valerie McGuire Weiva Sieh Paul D P Pharoah Honglin Song Jacek Gronwald Anna Jakubowska Cezary Cybulski Jan Lubinski Joellen M Schildkraut Andrew Berchuck Susanne Krüger Kjær Estrid Høgdall Peter A Fasching Matthias W Beckmann Arif B Ekici Alexander Hein Georgia Chenevix-Trench Penelope M Webb Jonathan Beesley Australian Ovarian Cancer Study Group Australian Cancer Study Group Marc T Goodman Ovarian Cancer Association Consortium Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium. PLoS ONE |
| title | Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium. |
| title_full | Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium. |
| title_fullStr | Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium. |
| title_full_unstemmed | Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium. |
| title_short | Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium. |
| title_sort | estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk pooled analysis within the ovarian cancer association consortium |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020703&type=printable |
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