IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
Two-hundred-eleven patients 3 to 14 years old (mean age 8.60±0.22 years) were observed and clinically evaluated at the Department of Pediatric Phthisiopulmonology, St.Petersburg Institute of Phthisiopulmonology during 2011-2013. The diagnostic protocol included: clinical data, X-rays diagnostics and...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-11-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/728 |
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| author | N. V. Korneva A. A. Starshinova Yu. E. Ovchinnikova E. I. Potapenko O. A. Yakunova I. F. Dovgalyuk |
| author_facet | N. V. Korneva A. A. Starshinova Yu. E. Ovchinnikova E. I. Potapenko O. A. Yakunova I. F. Dovgalyuk |
| author_sort | N. V. Korneva |
| collection | DOAJ |
| description | Two-hundred-eleven patients 3 to 14 years old (mean age 8.60±0.22 years) were observed and clinically evaluated at the Department of Pediatric Phthisiopulmonology, St.Petersburg Institute of Phthisiopulmonology during 2011-2013. The diagnostic protocol included: clinical data, X-rays diagnostics and immunologic assessment. All the patients were examined by DIASKINTEST® (DST) and QuantiferonTB Gold (QFT-G). They were divided into 2 groups, as based on laboratory data, as follows: group I (n= 63), patients with negative DST and QFT-G results; group II (n = 148), with positive results of specific tests. The study was aimed for intergroup comparisons of immune response markers. Positive results of DST and QFT-G suggested clinical activity of tuberculosis infection and are associated with high scores of tuberculin skin test (TST); increased cytokine levels (TNFα, IL-2, IFNγ), higher percentage of CD3+, CD4+ и CD95+ cells, elevated levels of specific IgG antibodies (anda TB ELISA); high titers of complement fixation test for mycobacteria, and activation of neutrophils. Positive results of DST and QFT-G in the patients are more often associated with active infection. |
| format | Article |
| id | doaj-art-8a0d9bef62d74b55ab506a9a883a9708 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-11-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-8a0d9bef62d74b55ab506a9a883a97082025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-11-0116542543010.15789/1563-0625-2014-5-425-430708IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITYN. V. Korneva0A. A. Starshinova1Yu. E. Ovchinnikova2E. I. Potapenko3O. A. Yakunova4I. F. Dovgalyuk5St. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health Care, St. Petersburg, Russian FederationSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health Care, St. Petersburg, Russian FederationSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health Care, St. Petersburg, Russian FederationSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health Care, St. Petersburg, Russian FederationSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health Care, St. Petersburg, Russian FederationSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health Care, St. Petersburg, Russian FederationTwo-hundred-eleven patients 3 to 14 years old (mean age 8.60±0.22 years) were observed and clinically evaluated at the Department of Pediatric Phthisiopulmonology, St.Petersburg Institute of Phthisiopulmonology during 2011-2013. The diagnostic protocol included: clinical data, X-rays diagnostics and immunologic assessment. All the patients were examined by DIASKINTEST® (DST) and QuantiferonTB Gold (QFT-G). They were divided into 2 groups, as based on laboratory data, as follows: group I (n= 63), patients with negative DST and QFT-G results; group II (n = 148), with positive results of specific tests. The study was aimed for intergroup comparisons of immune response markers. Positive results of DST and QFT-G suggested clinical activity of tuberculosis infection and are associated with high scores of tuberculin skin test (TST); increased cytokine levels (TNFα, IL-2, IFNγ), higher percentage of CD3+, CD4+ и CD95+ cells, elevated levels of specific IgG antibodies (anda TB ELISA); high titers of complement fixation test for mycobacteria, and activation of neutrophils. Positive results of DST and QFT-G in the patients are more often associated with active infection.https://www.mimmun.ru/mimmun/article/view/728tuberculosischildrenimmunitydiaskintest®quantiferon tb-gold |
| spellingShingle | N. V. Korneva A. A. Starshinova Yu. E. Ovchinnikova E. I. Potapenko O. A. Yakunova I. F. Dovgalyuk IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY Медицинская иммунология tuberculosis children immunity diaskintest® quantiferon tb-gold |
| title | IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY |
| title_full | IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY |
| title_fullStr | IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY |
| title_full_unstemmed | IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY |
| title_short | IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY |
| title_sort | immunologic parameters in children with tuberculosis infection of different activity |
| topic | tuberculosis children immunity diaskintest® quantiferon tb-gold |
| url | https://www.mimmun.ru/mimmun/article/view/728 |
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