Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection
The objective was to identify prognostic criteria for unfavorable outcome in pregnant women with severe and extremely severe forms of COVID-19 and to build a model for predicting clinical outcome.Materials and methods. The cohort single-center retrospective study was conducted, which included 83 pat...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2023-12-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/900 |
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| author | A. V. Shchegolev R. E. Lakhin A. A. Nikulin S. G. Meshchaninova V. F. Bezhenar |
| author_facet | A. V. Shchegolev R. E. Lakhin A. A. Nikulin S. G. Meshchaninova V. F. Bezhenar |
| author_sort | A. V. Shchegolev |
| collection | DOAJ |
| description | The objective was to identify prognostic criteria for unfavorable outcome in pregnant women with severe and extremely severe forms of COVID-19 and to build a model for predicting clinical outcome.Materials and methods. The cohort single-center retrospective study was conducted, which included 83 patients who were treated in the intensive care unit (ICU) from January 1 to December 31, 2021. Of these, 13 patients had an unfavorable outcome – death, and 70 patients with a successful outcome – recovery. The differences in the main clinical and laboratory parameters of patients of both groups during hospitalization in the ICU and on the 3rd day of treatment (Δ – delta) were analyzed.Results. The Cox regression analysis identified laboratory parameters, the difference of which (Δ) on admission to the ICU and on the 3rd day of treatment is associated with the development of the unfavorable outcome (death). These indicators were used as variables in a linear regression equation. The equation for calculating the prognostic index met the criteria of a statistically significant model (sensitivity 84.6 %, specificity 85.7 %, area under the operating characteristic curve (AUROC – Area Under Receiver Operator Curve) – 0.959 (95 % confidence interval [95 % CI] 0.918 – 1.0).Conclusion. The calculation of the prognostic index can be an additional clinical tool that allows one to predict the development of an unfavorable outcome, concentrate the work of a multidisciplinary team, attract additional reserves of a medical institution and/or evacuate such patients to high-level hospitals. |
| format | Article |
| id | doaj-art-8a0a8f17d23042519d0b0f045a8cf390 |
| institution | DOAJ |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-8a0a8f17d23042519d0b0f045a8cf3902025-08-20T02:59:42ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532023-12-01206586610.24884/2078-5658-2023-20-6-58-66642Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infectionA. V. Shchegolev0R. E. Lakhin1A. A. Nikulin2S. G. Meshchaninova3V. F. Bezhenar4Military Medical AcademyMilitary Medical AcademyMilitary Medical AcademyS. P. Botkin Clinical Infectious Diseases HospitalPavlov UniversityThe objective was to identify prognostic criteria for unfavorable outcome in pregnant women with severe and extremely severe forms of COVID-19 and to build a model for predicting clinical outcome.Materials and methods. The cohort single-center retrospective study was conducted, which included 83 patients who were treated in the intensive care unit (ICU) from January 1 to December 31, 2021. Of these, 13 patients had an unfavorable outcome – death, and 70 patients with a successful outcome – recovery. The differences in the main clinical and laboratory parameters of patients of both groups during hospitalization in the ICU and on the 3rd day of treatment (Δ – delta) were analyzed.Results. The Cox regression analysis identified laboratory parameters, the difference of which (Δ) on admission to the ICU and on the 3rd day of treatment is associated with the development of the unfavorable outcome (death). These indicators were used as variables in a linear regression equation. The equation for calculating the prognostic index met the criteria of a statistically significant model (sensitivity 84.6 %, specificity 85.7 %, area under the operating characteristic curve (AUROC – Area Under Receiver Operator Curve) – 0.959 (95 % confidence interval [95 % CI] 0.918 – 1.0).Conclusion. The calculation of the prognostic index can be an additional clinical tool that allows one to predict the development of an unfavorable outcome, concentrate the work of a multidisciplinary team, attract additional reserves of a medical institution and/or evacuate such patients to high-level hospitals.https://www.vair-journal.com/jour/article/view/900coronavirus infectionpregnancycovid-19maternal mortalitypredictors of unfavorable outcomeprognosis |
| spellingShingle | A. V. Shchegolev R. E. Lakhin A. A. Nikulin S. G. Meshchaninova V. F. Bezhenar Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection Вестник анестезиологии и реаниматологии coronavirus infection pregnancy covid-19 maternal mortality predictors of unfavorable outcome prognosis |
| title | Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection |
| title_full | Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection |
| title_fullStr | Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection |
| title_full_unstemmed | Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection |
| title_short | Prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection |
| title_sort | prediction of adverse clinical outcomes in pregnant women with severe and extremely severe forms of coronavirus infection |
| topic | coronavirus infection pregnancy covid-19 maternal mortality predictors of unfavorable outcome prognosis |
| url | https://www.vair-journal.com/jour/article/view/900 |
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