Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration
Biomedical scaffolds are increasingly used in bone repair due to their exceptional ability to support cell growth and proliferation. This study developed a multifunctional poly(lactic-co-glycolic acid) (PLGA)/polyvinyl alcohol (PVA)/metronidazole coaxial electrospun nanofiber membrane to overcome th...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/ada5bc |
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| _version_ | 1841526581064892416 |
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| author | Huinan Zhang Dongchao Ji Kunlong Zhao Zhuoheng Li Shuo Yang Peng Wang Wenxin Cao Yu Sun |
| author_facet | Huinan Zhang Dongchao Ji Kunlong Zhao Zhuoheng Li Shuo Yang Peng Wang Wenxin Cao Yu Sun |
| author_sort | Huinan Zhang |
| collection | DOAJ |
| description | Biomedical scaffolds are increasingly used in bone repair due to their exceptional ability to support cell growth and proliferation. This study developed a multifunctional poly(lactic-co-glycolic acid) (PLGA)/polyvinyl alcohol (PVA)/metronidazole coaxial electrospun nanofiber membrane to overcome the limitations of current bone tissue self-repair mechanisms. Optimization of the coaxial electrospinning parameters significantly improved the membrane’s overall performance. Mechanical property testing revealed that the tensile strength increased from 4.304 ± 0.079 MPa to 6.915 ± 0.032 MPa as the shell layer feeding rate was increased. Drug release studies demonstrated a marked reduction in the initial burst release of metronidazole as the shell layer thickness increased. The release amount decreased from 86% to 34% by the third hour, and the release continued over the course of one week. Furthermore, the in vitro release model transitioned from first-order kinetics to Peppas-Sahlin kinetics. In vitro studies confirmed that the metronidazole-loaded coaxial fiber membrane exhibited excellent biocompatibility, antibacterial properties, and osteogenic potential. In conclusion, PLGA/PVA controlled-release nanofiber membranes loaded with antibacterial drugs offer great promise for bone tissue regeneration therapies. |
| format | Article |
| id | doaj-art-8a092bc991be4d9484fa6233446ae47b |
| institution | Kabale University |
| issn | 2053-1591 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj-art-8a092bc991be4d9484fa6233446ae47b2025-01-16T16:43:23ZengIOP PublishingMaterials Research Express2053-15912025-01-0112101540310.1088/2053-1591/ada5bcPotential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regenerationHuinan Zhang0https://orcid.org/0009-0003-0302-3830Dongchao Ji1Kunlong Zhao2https://orcid.org/0000-0002-4261-3142Zhuoheng Li3Shuo Yang4Peng Wang5Wenxin Cao6Yu Sun7School of Stomatology, Harbin Medical University , First Affiliated Hospital of Harbin Medical University, Harbin 150000, People’s Republic of ChinaNational Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology , Harbin, 150080, People’s Republic of ChinaNational Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology , Harbin, 150080, People’s Republic of ChinaSchool of Stomatology, Harbin Medical University , First Affiliated Hospital of Harbin Medical University, Harbin 150000, People’s Republic of ChinaSchool of Stomatology, Harbin Medical University , First Affiliated Hospital of Harbin Medical University, Harbin 150000, People’s Republic of ChinaZhengzhou Research Institute, Harbin Institute of Technology , Zhengzhou 450000, People’s Republic of ChinaZhengzhou Research Institute, Harbin Institute of Technology , Zhengzhou 450000, People’s Republic of ChinaSchool of Stomatology, Harbin Medical University , First Affiliated Hospital of Harbin Medical University, Harbin 150000, People’s Republic of ChinaBiomedical scaffolds are increasingly used in bone repair due to their exceptional ability to support cell growth and proliferation. This study developed a multifunctional poly(lactic-co-glycolic acid) (PLGA)/polyvinyl alcohol (PVA)/metronidazole coaxial electrospun nanofiber membrane to overcome the limitations of current bone tissue self-repair mechanisms. Optimization of the coaxial electrospinning parameters significantly improved the membrane’s overall performance. Mechanical property testing revealed that the tensile strength increased from 4.304 ± 0.079 MPa to 6.915 ± 0.032 MPa as the shell layer feeding rate was increased. Drug release studies demonstrated a marked reduction in the initial burst release of metronidazole as the shell layer thickness increased. The release amount decreased from 86% to 34% by the third hour, and the release continued over the course of one week. Furthermore, the in vitro release model transitioned from first-order kinetics to Peppas-Sahlin kinetics. In vitro studies confirmed that the metronidazole-loaded coaxial fiber membrane exhibited excellent biocompatibility, antibacterial properties, and osteogenic potential. In conclusion, PLGA/PVA controlled-release nanofiber membranes loaded with antibacterial drugs offer great promise for bone tissue regeneration therapies.https://doi.org/10.1088/2053-1591/ada5bcpoly(lactic-co-glycolic acid)polyvinyl alcoholcoaxial electrospinningcontrolled drug releaseguided bone regeneration |
| spellingShingle | Huinan Zhang Dongchao Ji Kunlong Zhao Zhuoheng Li Shuo Yang Peng Wang Wenxin Cao Yu Sun Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration Materials Research Express poly(lactic-co-glycolic acid) polyvinyl alcohol coaxial electrospinning controlled drug release guided bone regeneration |
| title | Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration |
| title_full | Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration |
| title_fullStr | Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration |
| title_full_unstemmed | Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration |
| title_short | Potential applications of PLGA/PVA coaxial nanofibers with controlled release for guiding tissue regeneration |
| title_sort | potential applications of plga pva coaxial nanofibers with controlled release for guiding tissue regeneration |
| topic | poly(lactic-co-glycolic acid) polyvinyl alcohol coaxial electrospinning controlled drug release guided bone regeneration |
| url | https://doi.org/10.1088/2053-1591/ada5bc |
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