Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation
Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. These method...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1527854/full |
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| author | Nathalia Silva Dutra Alves Gustavo Roncoli Reigado Mayara Santos Izabela Daniel Sardinha Caldeira Henrique dos Santos Hernandes Bruna Leticia Freitas-Marchi Elina Zhivov Felipe Santiago Chambergo Viviane Abreu Nunes |
| author_facet | Nathalia Silva Dutra Alves Gustavo Roncoli Reigado Mayara Santos Izabela Daniel Sardinha Caldeira Henrique dos Santos Hernandes Bruna Leticia Freitas-Marchi Elina Zhivov Felipe Santiago Chambergo Viviane Abreu Nunes |
| author_sort | Nathalia Silva Dutra Alves |
| collection | DOAJ |
| description | Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. These methods hold promise for treating a range of conditions, from chronic wounds and burns to age-related skin changes and genetic disorders. Challenges remain in optimizing these therapies for broader accessibility and ensuring long-term safety and efficacy. |
| format | Article |
| id | doaj-art-8a090304717a4065a3c18baf892eb25b |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-8a090304717a4065a3c18baf892eb25b2025-02-12T07:25:41ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.15278541527854Advances in regenerative medicine-based approaches for skin regeneration and rejuvenationNathalia Silva Dutra Alves0Gustavo Roncoli Reigado1Mayara Santos2Izabela Daniel Sardinha Caldeira3Henrique dos Santos Hernandes4Bruna Leticia Freitas-Marchi5Elina Zhivov6Felipe Santiago Chambergo7Viviane Abreu Nunes8Laboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, BrazilLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, BrazilLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, BrazilLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, BrazilLaboratory of Proteins and Biotechnology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, BrazilLaboratory of Organic Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, SwedenWound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller Medical School, Miami, FL, United StatesLaboratory of Proteins and Biotechnology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, BrazilLaboratory of Skin Physiology and Tissue Bioengineering, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, BrazilSignificant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. These methods hold promise for treating a range of conditions, from chronic wounds and burns to age-related skin changes and genetic disorders. Challenges remain in optimizing these therapies for broader accessibility and ensuring long-term safety and efficacy.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1527854/fullskin regenerationrejuvenationregenerative medicinestem cellsbioengineered skin substituteswound healing |
| spellingShingle | Nathalia Silva Dutra Alves Gustavo Roncoli Reigado Mayara Santos Izabela Daniel Sardinha Caldeira Henrique dos Santos Hernandes Bruna Leticia Freitas-Marchi Elina Zhivov Felipe Santiago Chambergo Viviane Abreu Nunes Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation Frontiers in Bioengineering and Biotechnology skin regeneration rejuvenation regenerative medicine stem cells bioengineered skin substitutes wound healing |
| title | Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation |
| title_full | Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation |
| title_fullStr | Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation |
| title_full_unstemmed | Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation |
| title_short | Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation |
| title_sort | advances in regenerative medicine based approaches for skin regeneration and rejuvenation |
| topic | skin regeneration rejuvenation regenerative medicine stem cells bioengineered skin substitutes wound healing |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1527854/full |
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