Gene therapy in cardiomyopathies - Review of the latest reports
Introduction and purpose Gene therapy appears to be a promising treatment for patients with cardiomyopathy and innovative therapeutic option. The aim of this review is to present the latest gene therapy technologies, innovations, research in the treatment of cardiomyopathy and analysis of the eth...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nicolaus Copernicus University in Toruń
2025-07-01
|
| Series: | Quality in Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/QS/article/view/61280 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849704644291330048 |
|---|---|
| author | Magdalena Strzelczyk Gabriela Pabis Joanna Wziątek Paula Bętkowska Iwona Koziołek Piotr Kowalik Patrycja Fatyga Wiktoria Fatyga Daria Krzyżanowska Kinga Dowierciał |
| author_facet | Magdalena Strzelczyk Gabriela Pabis Joanna Wziątek Paula Bętkowska Iwona Koziołek Piotr Kowalik Patrycja Fatyga Wiktoria Fatyga Daria Krzyżanowska Kinga Dowierciał |
| author_sort | Magdalena Strzelczyk |
| collection | DOAJ |
| description |
Introduction and purpose
Gene therapy appears to be a promising treatment for patients with cardiomyopathy and innovative therapeutic option. The aim of this review is to present the latest gene therapy technologies, innovations, research in the treatment of cardiomyopathy and analysis of the ethical issues associated with the use of modern therapies.
Material and methods
This review is based on recent articles from the years 2020-2025 found in databases such PubMed, Elsevier.
Results
Gene editing through CRISPR-Cas technology allows for the modification of genetic material by making changes at precise locations what is highly useful in gene therapy. Gene Expression Regulation (RNAi) involves preventing the production of proteins by silencing a faulty gene. Antisense therapy (ASO) uses antisense oligonucleotides to exclude a particular exon and causes the translation process to stop. Gene replacement involves introducing a healthy copy of a mutated gene into the genome along with an appropriate vector.
Conclusions
Individual technologies in the treatment of cardiomyopathy show potential for treating patients in the future. It is also important to remember the ethical issues when using solutions based on gene therapy. Clinical trials in the future are necessary to further search for solutions for patients with cardiomyopathy.
|
| format | Article |
| id | doaj-art-8a06e395e1814b96aa61c4f65269455e |
| institution | DOAJ |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-8a06e395e1814b96aa61c4f65269455e2025-08-20T03:16:42ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-07-014310.12775/QS.2025.43.61280Gene therapy in cardiomyopathies - Review of the latest reportsMagdalena Strzelczyk0https://orcid.org/0009-0005-6312-3002Gabriela Pabis1https://orcid.org/0009-0002-3208-5160Joanna Wziątek 2https://orcid.org/0009-0002-1656-7477Paula Bętkowska 3https://orcid.org/0009-0002-7050-4039Iwona Koziołek 4https://orcid.org/0009-0002-1077-3640Piotr Kowalik 5https://orcid.org/0009-0009-4813-9742Patrycja Fatyga 6https://orcid.org/0009-0001-1277-1246Wiktoria Fatyga 7https://orcid.org/0009-0000-5931-925XDaria Krzyżanowska 8https://orcid.org/0009-0002-5349-5679Kinga Dowierciał 9https://orcid.org/0009-0000-9132-1026Municipal Medical Centre Jonscher in Łódź, Milionowa 14 Street, 93-113 Łódź, Poland The Provincial Hospital, Grunwaldzka 45, 25-736 Kielce, Poland Municipal Medical Centre Jonscher in Łódź, Milionowa 14 Street, 93-113 Łódź, Poland Municipal Medical Centre Jonscher in Łódź, Milionowa 14 Street, 93-113 Łódź, Poland The Provincial Hospital, Grunwaldzka 45, 25-736 Kielce, Poland Medical University of Lodz, Tadeusz Kościuszko Avenue 4, 90–419 Łódź, Poland The Provincial Hospital, Grunwaldzka 45, 25-736 Kielce, Poland Non-public Health Care Facility Prophylactics Wiesława Piotrowska Limited Liability Company, Jana Jeziorańskiego 137, 25-432 Kielce, Poland Municipal Medical Centre Jonscher in Łódź, Milionowa 14 Street, 93-113 Łódź, Poland Independent Public Regional Specialist Hospital in Chełm Ceramiczna 1 Street, 22-100 Chełm, Poland Introduction and purpose Gene therapy appears to be a promising treatment for patients with cardiomyopathy and innovative therapeutic option. The aim of this review is to present the latest gene therapy technologies, innovations, research in the treatment of cardiomyopathy and analysis of the ethical issues associated with the use of modern therapies. Material and methods This review is based on recent articles from the years 2020-2025 found in databases such PubMed, Elsevier. Results Gene editing through CRISPR-Cas technology allows for the modification of genetic material by making changes at precise locations what is highly useful in gene therapy. Gene Expression Regulation (RNAi) involves preventing the production of proteins by silencing a faulty gene. Antisense therapy (ASO) uses antisense oligonucleotides to exclude a particular exon and causes the translation process to stop. Gene replacement involves introducing a healthy copy of a mutated gene into the genome along with an appropriate vector. Conclusions Individual technologies in the treatment of cardiomyopathy show potential for treating patients in the future. It is also important to remember the ethical issues when using solutions based on gene therapy. Clinical trials in the future are necessary to further search for solutions for patients with cardiomyopathy. https://apcz.umk.pl/QS/article/view/61280cardiomyopathygene editingantisense therapygene expressiongene replacementethical issues |
| spellingShingle | Magdalena Strzelczyk Gabriela Pabis Joanna Wziątek Paula Bętkowska Iwona Koziołek Piotr Kowalik Patrycja Fatyga Wiktoria Fatyga Daria Krzyżanowska Kinga Dowierciał Gene therapy in cardiomyopathies - Review of the latest reports Quality in Sport cardiomyopathy gene editing antisense therapy gene expression gene replacement ethical issues |
| title | Gene therapy in cardiomyopathies - Review of the latest reports |
| title_full | Gene therapy in cardiomyopathies - Review of the latest reports |
| title_fullStr | Gene therapy in cardiomyopathies - Review of the latest reports |
| title_full_unstemmed | Gene therapy in cardiomyopathies - Review of the latest reports |
| title_short | Gene therapy in cardiomyopathies - Review of the latest reports |
| title_sort | gene therapy in cardiomyopathies review of the latest reports |
| topic | cardiomyopathy gene editing antisense therapy gene expression gene replacement ethical issues |
| url | https://apcz.umk.pl/QS/article/view/61280 |
| work_keys_str_mv | AT magdalenastrzelczyk genetherapyincardiomyopathiesreviewofthelatestreports AT gabrielapabis genetherapyincardiomyopathiesreviewofthelatestreports AT joannawziatek genetherapyincardiomyopathiesreviewofthelatestreports AT paulabetkowska genetherapyincardiomyopathiesreviewofthelatestreports AT iwonakoziołek genetherapyincardiomyopathiesreviewofthelatestreports AT piotrkowalik genetherapyincardiomyopathiesreviewofthelatestreports AT patrycjafatyga genetherapyincardiomyopathiesreviewofthelatestreports AT wiktoriafatyga genetherapyincardiomyopathiesreviewofthelatestreports AT dariakrzyzanowska genetherapyincardiomyopathiesreviewofthelatestreports AT kingadowierciał genetherapyincardiomyopathiesreviewofthelatestreports |