CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease that can cause low-grade chronic inflammation related to insulin resistance. Recently, neutrophil to lymphocyte has become a potential marker of chronic inflammation. An abnormal lipid profile occurs due to lipotoxicity from insulin...
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Faculty of Medicine, Universitas Diponegoro
2025-02-01
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| Series: | Jurnal Kedokteran Diponegoro |
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| Online Access: | https://ejournal3.undip.ac.id/index.php/medico/article/view/46358 |
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| author | Nadwa Izza Azuma Arifin Banundari Rachmawati Meita Hendrianingtyas Dwi Retnoningrum |
| author_facet | Nadwa Izza Azuma Arifin Banundari Rachmawati Meita Hendrianingtyas Dwi Retnoningrum |
| author_sort | Nadwa Izza Azuma Arifin |
| collection | DOAJ |
| description | Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease that can cause low-grade chronic inflammation related to insulin resistance. Recently, neutrophil to lymphocyte has become a potential marker of chronic inflammation. An abnormal lipid profile occurs due to lipotoxicity from insulin resistance. Objective: To prove the correlation between NLR and lipid profiles in T2DM patients. Methods: An analytic observational study used a cross-sectional approach to 45 medical records of T2DM patients who received treatment at Nasional Diponegoro Hospital Semarang. This study was conducted from October to November 2022. Data was collected by using consecutive sampling. Analysis of the correlation between NLR and lipid profiles used spearman’s correlation test. Results: The correlation between NLR and HDL cholesterol levels was p=0.035, r=-0.315. The correlation between NLR and cholesterol, LDL cholesterol, and triglyceride levels was p = 0.061, r = -0.281; p = 0.170, r = -0.208; p = 0.563, r = -0.089, respectively. Conclusion: There was a weak negative correlation between NLR and HDL cholesterol levels in T2DM patients, but there was no correlation between NLR and other lipid profiles. |
| format | Article |
| id | doaj-art-8a061a04d720411d9e98236dfa9f1985 |
| institution | DOAJ |
| issn | 2540-8844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Faculty of Medicine, Universitas Diponegoro |
| record_format | Article |
| series | Jurnal Kedokteran Diponegoro |
| spelling | doaj-art-8a061a04d720411d9e98236dfa9f19852025-08-20T03:23:59ZengFaculty of Medicine, Universitas DiponegoroJurnal Kedokteran Diponegoro2540-88442025-02-01142556110.14710/dmj.v14i2.4635833522CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUSNadwa Izza Azuma Arifin0Banundari Rachmawati1https://orcid.org/0000-0002-9181-5832Meita Hendrianingtyas2https://orcid.org/0000-0003-1554-2876Dwi Retnoningrum3https://orcid.org/0000-0003-1606-0078Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, IndonesiaBackground: Type 2 diabetes mellitus (T2DM) is a metabolic disease that can cause low-grade chronic inflammation related to insulin resistance. Recently, neutrophil to lymphocyte has become a potential marker of chronic inflammation. An abnormal lipid profile occurs due to lipotoxicity from insulin resistance. Objective: To prove the correlation between NLR and lipid profiles in T2DM patients. Methods: An analytic observational study used a cross-sectional approach to 45 medical records of T2DM patients who received treatment at Nasional Diponegoro Hospital Semarang. This study was conducted from October to November 2022. Data was collected by using consecutive sampling. Analysis of the correlation between NLR and lipid profiles used spearman’s correlation test. Results: The correlation between NLR and HDL cholesterol levels was p=0.035, r=-0.315. The correlation between NLR and cholesterol, LDL cholesterol, and triglyceride levels was p = 0.061, r = -0.281; p = 0.170, r = -0.208; p = 0.563, r = -0.089, respectively. Conclusion: There was a weak negative correlation between NLR and HDL cholesterol levels in T2DM patients, but there was no correlation between NLR and other lipid profiles.https://ejournal3.undip.ac.id/index.php/medico/article/view/46358nlr, cholesterol, hdl, ldl, triglyceride |
| spellingShingle | Nadwa Izza Azuma Arifin Banundari Rachmawati Meita Hendrianingtyas Dwi Retnoningrum CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS Jurnal Kedokteran Diponegoro nlr, cholesterol, hdl, ldl, triglyceride |
| title | CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS |
| title_full | CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS |
| title_fullStr | CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS |
| title_full_unstemmed | CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS |
| title_short | CORRELATION BETWEEN NEUTROPHIL-LYMPHOCYTE RATIO AND LIPID PROFILE IN TYPE-2 DIABETES MELLITUS |
| title_sort | correlation between neutrophil lymphocyte ratio and lipid profile in type 2 diabetes mellitus |
| topic | nlr, cholesterol, hdl, ldl, triglyceride |
| url | https://ejournal3.undip.ac.id/index.php/medico/article/view/46358 |
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