Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China
Although prior studies have identified that per- and polyfluoroalkyl substances (PFASs) were associated with adverse pregnancy outcomes, the potential influence of PFASs exposure on unexplained recurrent spontaneous abortion (URSA) remains uncertain. Our case-control study aimed to explore the assoc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325008413 |
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| author | Qianxi Cheng Chunxian Lv Yawei Li Haocan Song Shuyao Li Dandan Li Yingying Han Feng Zhao Qiang Lin |
| author_facet | Qianxi Cheng Chunxian Lv Yawei Li Haocan Song Shuyao Li Dandan Li Yingying Han Feng Zhao Qiang Lin |
| author_sort | Qianxi Cheng |
| collection | DOAJ |
| description | Although prior studies have identified that per- and polyfluoroalkyl substances (PFASs) were associated with adverse pregnancy outcomes, the potential influence of PFASs exposure on unexplained recurrent spontaneous abortion (URSA) remains uncertain. Our case-control study aimed to explore the associations between PFASs and URSA, including 110 URSA cases and 91 controls from Beijing. Concentrations of 15 PFASs in serum were measured using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The associations between PFASs and the risk of URSA were then analyzed using multiple logistic regression. Compared to the lowest tertile, PFBA (2nd (OR: 4.26; 95 % CI: 1.92, 9.45), 3rd (OR: 8.10; 95 % CI: 3.48, 18.89)), PFDoDA (2nd (OR: 2.17; 95 % CI: 1.72, 4.35), 3rd (OR: 3.18; 95 % CI: 2.24, 4.85)), PFHxS (3rd (OR: 2.46; 95 % CI: 1.15, 5.25) and PFHpS (3rd (OR: 2.56; 95 % CI: 1.15, 5.69) were positively associated with higher risks of URSA. 6:2 Cl-PFESA was significantly associated with decreased risks of URSA. Weighted quantile sum (WQS) regression analyses, Quantile g-computation (QGC) and Bayesian kernel machine regression (BKMR) identified PFBA and PFDoDA as the primary contributors to the mixed effects of PFASs on URSA. We found that maternal serum PFASs, especially PFBA and PFDoDA may increase the risk of URSA. |
| format | Article |
| id | doaj-art-8a05f764a2c743bc80886a70e3dcd083 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-8a05f764a2c743bc80886a70e3dcd0832025-08-20T03:21:59ZengElsevierEcotoxicology and Environmental Safety0147-65132025-08-0130111849610.1016/j.ecoenv.2025.118496Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in ChinaQianxi Cheng0Chunxian Lv1Yawei Li2Haocan Song3Shuyao Li4Dandan Li5Yingying Han6Feng Zhao7Qiang Lin8China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, ChinaFengtai District Center for Disease Control and Prevention, Beijing 100071, ChinaFengtai District Center for Disease Control and Prevention, Beijing 100071, ChinaChina CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; Correspondence to: National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, #29 Nanweilu, Xicheng, Beijing 100050, China.Beijing Yanqing District Center for Disease Control and Prevention, Beijing 102100, China; Correspondence to: Beijing Yanqing District Center for Disease Prevention and Control, #39 Baiquanlu, Yanqing, Beijing 102100, China.Although prior studies have identified that per- and polyfluoroalkyl substances (PFASs) were associated with adverse pregnancy outcomes, the potential influence of PFASs exposure on unexplained recurrent spontaneous abortion (URSA) remains uncertain. Our case-control study aimed to explore the associations between PFASs and URSA, including 110 URSA cases and 91 controls from Beijing. Concentrations of 15 PFASs in serum were measured using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The associations between PFASs and the risk of URSA were then analyzed using multiple logistic regression. Compared to the lowest tertile, PFBA (2nd (OR: 4.26; 95 % CI: 1.92, 9.45), 3rd (OR: 8.10; 95 % CI: 3.48, 18.89)), PFDoDA (2nd (OR: 2.17; 95 % CI: 1.72, 4.35), 3rd (OR: 3.18; 95 % CI: 2.24, 4.85)), PFHxS (3rd (OR: 2.46; 95 % CI: 1.15, 5.25) and PFHpS (3rd (OR: 2.56; 95 % CI: 1.15, 5.69) were positively associated with higher risks of URSA. 6:2 Cl-PFESA was significantly associated with decreased risks of URSA. Weighted quantile sum (WQS) regression analyses, Quantile g-computation (QGC) and Bayesian kernel machine regression (BKMR) identified PFBA and PFDoDA as the primary contributors to the mixed effects of PFASs on URSA. We found that maternal serum PFASs, especially PFBA and PFDoDA may increase the risk of URSA.http://www.sciencedirect.com/science/article/pii/S0147651325008413Per- and polyfluoroalkyl substancesUnexplained recurrent spontaneous abortionCase-control study |
| spellingShingle | Qianxi Cheng Chunxian Lv Yawei Li Haocan Song Shuyao Li Dandan Li Yingying Han Feng Zhao Qiang Lin Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China Ecotoxicology and Environmental Safety Per- and polyfluoroalkyl substances Unexplained recurrent spontaneous abortion Case-control study |
| title | Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China |
| title_full | Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China |
| title_fullStr | Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China |
| title_full_unstemmed | Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China |
| title_short | Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China |
| title_sort | association between per and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion a case control study in china |
| topic | Per- and polyfluoroalkyl substances Unexplained recurrent spontaneous abortion Case-control study |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325008413 |
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