Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features
Hybrid Peripheral Nerve Sheath Tumors (HPNSTs) are rare benign neoplasms that exhibit a combination of histological features from multiple types of benign peripheral nerve sheath tumors, including schwannomas, neurofibromas, and perineuriomas. These tumors present a diagnostic challenge due to their...
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MDPI AG
2025-03-01
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| author | Serena Salzano Rosario Caltabiano Magda Zanelli Andrea Palicelli Maurizio Zizzo Nektarios Koufopoulos Ioannis Boutas Gaetano Magro Valeria Barresi Giuseppe Broggi |
| author_facet | Serena Salzano Rosario Caltabiano Magda Zanelli Andrea Palicelli Maurizio Zizzo Nektarios Koufopoulos Ioannis Boutas Gaetano Magro Valeria Barresi Giuseppe Broggi |
| author_sort | Serena Salzano |
| collection | DOAJ |
| description | Hybrid Peripheral Nerve Sheath Tumors (HPNSTs) are rare benign neoplasms that exhibit a combination of histological features from multiple types of benign peripheral nerve sheath tumors, including schwannomas, neurofibromas, and perineuriomas. These tumors present a diagnostic challenge due to their morphological and histological variability. In this article, we aim to summarize the key morphological, histological, and molecular characteristics of HPNSTs, providing insights into their diagnostic approaches. We review the different hybrid subtypes, including schwannoma–perineurioma, schwannoma–neurofibroma, and perineurioma–neurofibroma, emphasizing their clinical features, genetic associations, and the role of surgical excision as the gold-standard treatment. |
| format | Article |
| id | doaj-art-8a05b9ab67b14addb18700d2eb4fbedd |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-8a05b9ab67b14addb18700d2eb4fbedd2025-08-20T02:15:55ZengMDPI AGDiagnostics2075-44182025-03-0115785510.3390/diagnostics15070855Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic FeaturesSerena Salzano0Rosario Caltabiano1Magda Zanelli2Andrea Palicelli3Maurizio Zizzo4Nektarios Koufopoulos5Ioannis Boutas6Gaetano Magro7Valeria Barresi8Giuseppe Broggi9Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalySurgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalySecond Department of Pathology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, 15772 Athens, GreeceSecond Department of Pathology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, 15772 Athens, GreeceDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, ItalyDepartment of Diagnostics and Public Health, University of Verona, 37134 Verona, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, ItalyHybrid Peripheral Nerve Sheath Tumors (HPNSTs) are rare benign neoplasms that exhibit a combination of histological features from multiple types of benign peripheral nerve sheath tumors, including schwannomas, neurofibromas, and perineuriomas. These tumors present a diagnostic challenge due to their morphological and histological variability. In this article, we aim to summarize the key morphological, histological, and molecular characteristics of HPNSTs, providing insights into their diagnostic approaches. We review the different hybrid subtypes, including schwannoma–perineurioma, schwannoma–neurofibroma, and perineurioma–neurofibroma, emphasizing their clinical features, genetic associations, and the role of surgical excision as the gold-standard treatment.https://www.mdpi.com/2075-4418/15/7/855hybrid benign peripheral nerve sheath tumorsCNSschwannomaneurofibromaperineurioma |
| spellingShingle | Serena Salzano Rosario Caltabiano Magda Zanelli Andrea Palicelli Maurizio Zizzo Nektarios Koufopoulos Ioannis Boutas Gaetano Magro Valeria Barresi Giuseppe Broggi Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features Diagnostics hybrid benign peripheral nerve sheath tumors CNS schwannoma neurofibroma perineurioma |
| title | Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features |
| title_full | Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features |
| title_fullStr | Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features |
| title_full_unstemmed | Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features |
| title_short | Hybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features |
| title_sort | hybrid benign peripheral nerve sheath tumors a comprehensive literature review with emphasis on their clinical morphological and genetic features |
| topic | hybrid benign peripheral nerve sheath tumors CNS schwannoma neurofibroma perineurioma |
| url | https://www.mdpi.com/2075-4418/15/7/855 |
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