Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase

Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase

Saved in:

Bibliographic Details
Main Authors:	Jiaqian Wu, Marek R. Baranowski, Alexander E. Aleshin, Eta A. Isiorho, Lester J. Lambert, Laurent J. S. De Backer, Ye Na Han, Ranajit Das, Douglas J. Sheffler, Andrey A. Bobkov, Alexis M. Lemberikman, Daniel A. Keedy, Nicholas D. P. Cosford, Lutz Tautz
Format:	Article
Language:	English
Published:	American Chemical Society 2025-01-01
Series:	ACS Omega
Online Access:	https://doi.org/10.1021/acsomega.4c10321
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Urban Surface Water Mapping from VHR Images Based on Superpixel Segmentation and Target Detection
by: Qingwei Liu, et al.
Published: (2022-01-01)

Discovery of potent allosteric antibodies inhibiting EGFR
by: Léxane Fournier, et al.
Published: (2024-12-01)

Multiscale Region-Level VHR Image Change Detection via Sparse Change Descriptor and Robust Discriminative Dictionary Learning
by: Yuan Xu, et al.
Published: (2015-01-01)

USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins
by: Xu Y, et al.
Published: (2025-02-01)

Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
by: Lulu Yao, et al.
Published: (2017-01-01)

Conformational diversity in class C GPCR positive allosteric modulation
by: Giuseppe Cannone, et al.
Published: (2025-01-01)

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease
by: Thomas F Baumert, et al.
Published: (2025-01-01)

Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10
by: Jiaojiao Zhu, et al.
Published: (2025-02-01)

Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents
by: Frank Mazza, et al.
Published: (2025-03-01)

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy
by: Tjaša Goričan, et al.
Published: (2024-12-01)

Single-Molecule Analysis of Alkaline Phosphatase
by: Douglas B. Craig
Published: (2024-10-01)

Long Noncoding RNA SNHG4 Attenuates the Injury of Myocardial Infarction via Regulating miR-148b-3p/DUSP1 Axis
by: Sheng Wang, et al.
Published: (2022-01-01)

The efficacy of an allosteric modulator of the alpha 7 nicotinic acetylcholine receptor in a murine model of stroke
by: Katherine Hernandez, et al.
Published: (2025-02-01)

Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator
by: Rahma Aly, et al.
Published: (2025-02-01)

Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways
by: Renee Hastings, et al.
Published: (2025-01-01)

Protein Phosphatase 2A: Role in T Cells and Diseases
by: Suyasha Roy, et al.
Published: (2023-01-01)

A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action
by: Shira Cohen, et al.
Published: (2014-01-01)

Correction: LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
by: Jui-Hung Weng, et al.
Published: (2025-02-01)

Expression of protein phosphatase 4 in different tissues under hypoxia
by: Yanyan Ma, et al.
Published: (2023-07-01)

Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery
by: Xin Qiao, et al.
Published: (2025-02-01)

Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy
by: Amaury Herbet, et al.
Published: (2025-01-01)

Biochemical characterization of the human ubiquitous glucose‐6‐phosphatase in neutrophil granulocytes
by: Zsigmond Lédeczi, et al.
Published: (2025-02-01)

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs
by: Gennady G. Yegutkin, et al.
Published: (2014-01-01)

Myotubularin-Related Phosphatase 3 Promotes Growth of Colorectal Cancer Cells
by: Bo’an Zheng, et al.
Published: (2014-01-01)

Identification of Antiapoptotic Protein Kinases and Phosphatases by a Functional Genomics Approach
by: Reimar Abraham, et al.
Published: (2001-01-01)

Serum Alkaline Phosphatase in Free-Ranging Male Moose Alces alces (Linnaeus 1758) of Different Age Groups
by: Maria A. Perevozchikova, et al.
Published: (2023-12-01)

Expression Profile of Tyrosine Phosphatases in HER2 Breast Cancer Cells and Tumors
by: Maria Antonietta Lucci, et al.
Published: (2010-01-01)

Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma
by: Jongmin Sim, et al.
Published: (2015-01-01)

Application of Intracellular Alkaline Phosphatase Activity Measurement in Detection of Neutrophil Adherence In Vitro
by: Katarzyna Bednarska, et al.
Published: (2006-01-01)

Representing and Quantifying Conformational Changes of Kinases and Phosphatases Using the TSR-Based Algorithm
by: Tarikul I. Milon, et al.
Published: (2024-11-01)

Variation of Photosynthesis, Fatty Acid Composition, ATPase and Acid Phosphatase Activities, and Anatomical Structure of Two Tea (Camellia sinensis (L.) O. Kuntze) Cultivars in Response to Fluoride
by: L. X. Wang, et al.
Published: (2013-01-01)

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i>
by: Hovakim Grabski, et al.
Published: (2024-12-01)

Allosteric Fluorescent Detection of Saccharides and Biomolecules in Water from a Boronic Acid Functionalized Arene Ruthenium Assembly Hosting Fluorescent Dyes
by: Alaa Maatouk, et al.
Published: (2024-12-01)

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia
by: David Olivares-Berjaga, et al.
Published: (2025-01-01)

Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice
by: Tse-Ching Chen, et al.
Published: (2025-02-01)

Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance
by: I. Ramasamy
Published: (2020-01-01)

Expression of Dual-Specificity Phosphatase 9 in Placenta and Its Relationship with Gestational Diabetes Mellitus
by: Qiang Wei, et al.
Published: (2019-01-01)

Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity
by: Spike Murphy Müller, et al.
Published: (2025-01-01)

The Fluorescent Detection of Alkaline Phosphatase Based on Iron Nanoclusters and a Manganese Dioxide Nanosheet
by: Liang Zhao, et al.
Published: (2025-01-01)

The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases
by: Geordan J. Stukey, et al.
Published: (2025-01-01)