Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents
Abstract Pluronic F127 copolymer is used as the main component to design injectable gels for therapeutic applications. Xanthan gum is added as an excipient to improve gel properties under physiological conditions. A polyphenol bioactive compound, curcumin, is selected as therapeutic agent with benef...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-04-01
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| Series: | Macromolecular Materials and Engineering |
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| Online Access: | https://doi.org/10.1002/mame.202400341 |
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| author | Alexandra Lupu Maria Bercea Mihaela Avadanei Luiza Madalina Gradinaru Loredana Elena Nita Vasile Robert Gradinaru |
| author_facet | Alexandra Lupu Maria Bercea Mihaela Avadanei Luiza Madalina Gradinaru Loredana Elena Nita Vasile Robert Gradinaru |
| author_sort | Alexandra Lupu |
| collection | DOAJ |
| description | Abstract Pluronic F127 copolymer is used as the main component to design injectable gels for therapeutic applications. Xanthan gum is added as an excipient to improve gel properties under physiological conditions. A polyphenol bioactive compound, curcumin, is selected as therapeutic agent with beneficial effects on metabolism and many diseases. The encapsulation efficiency and stability of formulations are investigated in an aqueous environment and in acetic acid solutions. The interactions between the hydrophobic polyphenol and the polymer matrix are investigated through rheology, DLS, and FTIR spectroscopy. The viscoelasticity of gels, correlated with the network structure, is influenced by xanthan gum or acetic acid addition. FTIR analysis of curcumin incorporated into the gel provides the evidence for interaction of the phenyl rings of both keto‐enol and di‐keto tautomers with the polymeric matrix. The spherical curcumin‐encapsulated micelles provided antioxidant properties. The kinetics of curcumin release from the Pluronic F127‐based gels suggests anomalous transport phenomena controlled by diffusion through the network and hydrodynamic effects. Both gel and lyophilized form of micellar encapsulated curcumin composites exhibited good stability for long‐term storage under ambient conditions. |
| format | Article |
| id | doaj-art-8a02a77db54c4ff2b5cf2866c03d3c22 |
| institution | OA Journals |
| issn | 1438-7492 1439-2054 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj-art-8a02a77db54c4ff2b5cf2866c03d3c222025-08-20T02:26:36ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-04-013104n/an/a10.1002/mame.202400341Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic AgentsAlexandra Lupu0Maria Bercea1Mihaela Avadanei2Luiza Madalina Gradinaru3Loredana Elena Nita4Vasile Robert Gradinaru5“Petru Poni” Institute of Macromolecular Chemistry 41‐A Grigore Ghica Voda Alley Iasi 700487 Romania“Petru Poni” Institute of Macromolecular Chemistry 41‐A Grigore Ghica Voda Alley Iasi 700487 Romania“Petru Poni” Institute of Macromolecular Chemistry 41‐A Grigore Ghica Voda Alley Iasi 700487 Romania“Petru Poni” Institute of Macromolecular Chemistry 41‐A Grigore Ghica Voda Alley Iasi 700487 Romania“Petru Poni” Institute of Macromolecular Chemistry 41‐A Grigore Ghica Voda Alley Iasi 700487 RomaniaFaculty of Chemistry Alexandru Ioan Cuza University of Iasi 11 Carol I Bd. Iasi 700506 RomaniaAbstract Pluronic F127 copolymer is used as the main component to design injectable gels for therapeutic applications. Xanthan gum is added as an excipient to improve gel properties under physiological conditions. A polyphenol bioactive compound, curcumin, is selected as therapeutic agent with beneficial effects on metabolism and many diseases. The encapsulation efficiency and stability of formulations are investigated in an aqueous environment and in acetic acid solutions. The interactions between the hydrophobic polyphenol and the polymer matrix are investigated through rheology, DLS, and FTIR spectroscopy. The viscoelasticity of gels, correlated with the network structure, is influenced by xanthan gum or acetic acid addition. FTIR analysis of curcumin incorporated into the gel provides the evidence for interaction of the phenyl rings of both keto‐enol and di‐keto tautomers with the polymeric matrix. The spherical curcumin‐encapsulated micelles provided antioxidant properties. The kinetics of curcumin release from the Pluronic F127‐based gels suggests anomalous transport phenomena controlled by diffusion through the network and hydrodynamic effects. Both gel and lyophilized form of micellar encapsulated curcumin composites exhibited good stability for long‐term storage under ambient conditions.https://doi.org/10.1002/mame.202400341Antioxidant PropertiesCurcuminPluronic F127Thermosensitive GelViscoelasticityXanthan Gum |
| spellingShingle | Alexandra Lupu Maria Bercea Mihaela Avadanei Luiza Madalina Gradinaru Loredana Elena Nita Vasile Robert Gradinaru Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents Macromolecular Materials and Engineering Antioxidant Properties Curcumin Pluronic F127 Thermosensitive Gel Viscoelasticity Xanthan Gum |
| title | Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents |
| title_full | Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents |
| title_fullStr | Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents |
| title_full_unstemmed | Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents |
| title_short | Temperature Sensitive Pluronic F127‐Based Gels Incorporating Natural Therapeutic Agents |
| title_sort | temperature sensitive pluronic f127 based gels incorporating natural therapeutic agents |
| topic | Antioxidant Properties Curcumin Pluronic F127 Thermosensitive Gel Viscoelasticity Xanthan Gum |
| url | https://doi.org/10.1002/mame.202400341 |
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