Clinical value of dysregulated miR-125b-5p in severe pneumonia children
Abstract Background Severe pneumonia is an important contributor to the high mortality of sick young children. The microRNA-125b-5p (miR-125b-5p), which is widely involved in various cancers, is closely related to a variety of lung diseases. However, its role in severe pneumonia children remains to...
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BMC
2025-04-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-025-00707-6 |
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| author | Meiqin Zhu Ziyan Lu Xingjuan Liao Qin Liang Chao Xu Xinbing Luo Jun Li |
| author_facet | Meiqin Zhu Ziyan Lu Xingjuan Liao Qin Liang Chao Xu Xinbing Luo Jun Li |
| author_sort | Meiqin Zhu |
| collection | DOAJ |
| description | Abstract Background Severe pneumonia is an important contributor to the high mortality of sick young children. The microRNA-125b-5p (miR-125b-5p), which is widely involved in various cancers, is closely related to a variety of lung diseases. However, its role in severe pneumonia children remains to be studied. Objective This study focused on the expression and clinical value of miR-125b-5p in severe pneumonia children. Materials and methods The study subjects included 96 pneumonia children and 127 severe pneumonia children. These children were aged between 2-10 years. The expression level of serum miR-125b-5p was assessed by qRT-PCR. The receiver operator characteristic (ROC) curve was employed to identify severe pneumonia children from pneumonia individuals. Kaplan-Meier curve was plotted based on follow-up results and multivariate Cox regression analysis was applied to evaluate the contribution of miR-125b-5p to poor prognostic in severe pneumonia children. Results MiR-125b-5p was remarkedly reduced in severe pneumonia children compared to pneumonia individuals. The area under the curve (AUC) was 0.9267 and the sensitivity and specificity were 84.25% and 89.58%, respectively. The accumulative survival rate in low miR-125b-5p group showed a remarkable decrease compared to the high miR-125b-5p group (P = 0.033). Increased procalcitonin (PCT, HR: 2.631, 95% CI: 1.029–6.732, P = 0.043) and reduced miR-125b-5p (HR: 0.301, 95% CI: 0.110–0.826, P = 0.020) were found to be related to the poor prognosis in severe pneumonia children. Conclusion The reduced miR-125b-5p was an underlying diagnostic indicator of severe pneumonia and was an independent risk factor of poor prognosis in severe pneumonia children. |
| format | Article |
| id | doaj-art-89ff883e38d54c5fab79ad97d8ca69c7 |
| institution | DOAJ |
| issn | 1471-2172 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj-art-89ff883e38d54c5fab79ad97d8ca69c72025-08-20T03:10:06ZengBMCBMC Immunology1471-21722025-04-012611610.1186/s12865-025-00707-6Clinical value of dysregulated miR-125b-5p in severe pneumonia childrenMeiqin Zhu0Ziyan Lu1Xingjuan Liao2Qin Liang3Chao Xu4Xinbing Luo5Jun Li6Department of Respiratory, The Fourth Affiliated Hospital of Jiangsu University (Zhenjiang Maternal and Child Health Hospital)Department of Pediatrics, Women and Children’s Hospital, Qingdao UniversityDepartment of Pediatrics, Taihe Hospital, Affiliated Hospital of Hubei University of MedicineDepartment of Pediatrics, Taihe Hospital, Affiliated Hospital of Hubei University of MedicineDepartment of Pediatrics, Taihe Hospital, Affiliated Hospital of Hubei University of MedicineDepartment of Pediatrics, Taihe Hospital, Affiliated Hospital of Hubei University of MedicineDepartment of Integrated Traditional Chinese and Western Medicine, Xi’an Children’s Hospital, The Affiliated Children’s Hospital of Xi’an Jiaotong UniversityAbstract Background Severe pneumonia is an important contributor to the high mortality of sick young children. The microRNA-125b-5p (miR-125b-5p), which is widely involved in various cancers, is closely related to a variety of lung diseases. However, its role in severe pneumonia children remains to be studied. Objective This study focused on the expression and clinical value of miR-125b-5p in severe pneumonia children. Materials and methods The study subjects included 96 pneumonia children and 127 severe pneumonia children. These children were aged between 2-10 years. The expression level of serum miR-125b-5p was assessed by qRT-PCR. The receiver operator characteristic (ROC) curve was employed to identify severe pneumonia children from pneumonia individuals. Kaplan-Meier curve was plotted based on follow-up results and multivariate Cox regression analysis was applied to evaluate the contribution of miR-125b-5p to poor prognostic in severe pneumonia children. Results MiR-125b-5p was remarkedly reduced in severe pneumonia children compared to pneumonia individuals. The area under the curve (AUC) was 0.9267 and the sensitivity and specificity were 84.25% and 89.58%, respectively. The accumulative survival rate in low miR-125b-5p group showed a remarkable decrease compared to the high miR-125b-5p group (P = 0.033). Increased procalcitonin (PCT, HR: 2.631, 95% CI: 1.029–6.732, P = 0.043) and reduced miR-125b-5p (HR: 0.301, 95% CI: 0.110–0.826, P = 0.020) were found to be related to the poor prognosis in severe pneumonia children. Conclusion The reduced miR-125b-5p was an underlying diagnostic indicator of severe pneumonia and was an independent risk factor of poor prognosis in severe pneumonia children.https://doi.org/10.1186/s12865-025-00707-6miR-125b-5pDiagnosisPrognosisSevere pneumonia |
| spellingShingle | Meiqin Zhu Ziyan Lu Xingjuan Liao Qin Liang Chao Xu Xinbing Luo Jun Li Clinical value of dysregulated miR-125b-5p in severe pneumonia children BMC Immunology miR-125b-5p Diagnosis Prognosis Severe pneumonia |
| title | Clinical value of dysregulated miR-125b-5p in severe pneumonia children |
| title_full | Clinical value of dysregulated miR-125b-5p in severe pneumonia children |
| title_fullStr | Clinical value of dysregulated miR-125b-5p in severe pneumonia children |
| title_full_unstemmed | Clinical value of dysregulated miR-125b-5p in severe pneumonia children |
| title_short | Clinical value of dysregulated miR-125b-5p in severe pneumonia children |
| title_sort | clinical value of dysregulated mir 125b 5p in severe pneumonia children |
| topic | miR-125b-5p Diagnosis Prognosis Severe pneumonia |
| url | https://doi.org/10.1186/s12865-025-00707-6 |
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