Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities
Abstract Prostate cancer (PC) is a significant global health concern, particularly among older men (OM), and smoking is a well-established modifiable risk factor contributing to its incidence and mortality. However, a comprehensive assessment of the global burden of PC attributable to smoking among...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-16160-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226435209723904 |
|---|---|
| author | Hao Chen Chen Sang Jia Jia Shan Zheng Minzhen Wang |
| author_facet | Hao Chen Chen Sang Jia Jia Shan Zheng Minzhen Wang |
| author_sort | Hao Chen |
| collection | DOAJ |
| description | Abstract Prostate cancer (PC) is a significant global health concern, particularly among older men (OM), and smoking is a well-established modifiable risk factor contributing to its incidence and mortality. However, a comprehensive assessment of the global burden of PC attributable to smoking among OM, with specific analyses by age and Socio-demographic Index (SDI) regions, is still lacking. This study utilized data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 to systematically analyze the global burden of PC attributable to smoking among OM (aged 55 years and older) from 1990 to 2021. The analysis included trends in deaths and Disability-Adjusted Life Years (DALYs) across different age groups and SDI regions. The estimated annual percentage change (EAPC) and Joinpoint regression analysis were employed to assess temporal trends. From 1990 to 2021, the global burden of PC attributable to smoking among OM exhibited a significant decline, with the age-standardized death rate decreasing from 3.08 per 100,000 in 1990 to 1.80 per 100,000 in 2021 (EAPC: -2.02, 95% CI: -2.14 to -1.90). Similarly, the age-standardized DALY rate decreased from 65.28 per 100,000 in 1990 to 37.75 per 100,000 in 2021 (EAPC: -2.05, 95% CI: -2.16 to -1.94). However, disparities across SDI regions were evident. The high SDI region experienced the most substantial decline in burden. In contrast, the low-middle SDI region showed an increasing trend, highlighting enduring socioeconomic disparities. Notably, Despite the overall reduction in the global burden, the burden among the older age group, specifically 90–95 years old, remained the most severe in 2021. This study reveals a complex landscape of the global burden of PC attributable to smoking among OM, with an overall decline masking enduring socioeconomic disparities and a severe burden among the older age group. These findings underscore the need for targeted interventions and public health strategies to address these disparities. Future efforts should focus on implementing smoking cessation programs and improving healthcare access in vulnerable populations. |
| format | Article |
| id | doaj-art-89f13ff0da08427fb1ea333aa54bc02a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-89f13ff0da08427fb1ea333aa54bc02a2025-08-24T11:21:20ZengNature PortfolioScientific Reports2045-23222025-08-0115111810.1038/s41598-025-16160-9Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparitiesHao Chen0Chen Sang1Jia Jia2Shan Zheng3Minzhen Wang4Department of Epidemiology and Statistics, School of Public Health, Lanzhou UniversityDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou UniversityDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou UniversityDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou UniversityDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou UniversityAbstract Prostate cancer (PC) is a significant global health concern, particularly among older men (OM), and smoking is a well-established modifiable risk factor contributing to its incidence and mortality. However, a comprehensive assessment of the global burden of PC attributable to smoking among OM, with specific analyses by age and Socio-demographic Index (SDI) regions, is still lacking. This study utilized data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 to systematically analyze the global burden of PC attributable to smoking among OM (aged 55 years and older) from 1990 to 2021. The analysis included trends in deaths and Disability-Adjusted Life Years (DALYs) across different age groups and SDI regions. The estimated annual percentage change (EAPC) and Joinpoint regression analysis were employed to assess temporal trends. From 1990 to 2021, the global burden of PC attributable to smoking among OM exhibited a significant decline, with the age-standardized death rate decreasing from 3.08 per 100,000 in 1990 to 1.80 per 100,000 in 2021 (EAPC: -2.02, 95% CI: -2.14 to -1.90). Similarly, the age-standardized DALY rate decreased from 65.28 per 100,000 in 1990 to 37.75 per 100,000 in 2021 (EAPC: -2.05, 95% CI: -2.16 to -1.94). However, disparities across SDI regions were evident. The high SDI region experienced the most substantial decline in burden. In contrast, the low-middle SDI region showed an increasing trend, highlighting enduring socioeconomic disparities. Notably, Despite the overall reduction in the global burden, the burden among the older age group, specifically 90–95 years old, remained the most severe in 2021. This study reveals a complex landscape of the global burden of PC attributable to smoking among OM, with an overall decline masking enduring socioeconomic disparities and a severe burden among the older age group. These findings underscore the need for targeted interventions and public health strategies to address these disparities. Future efforts should focus on implementing smoking cessation programs and improving healthcare access in vulnerable populations.https://doi.org/10.1038/s41598-025-16160-9Prostate cancerSmokingOld menGlobal burden of diseaseDisability-adjusted life yearsSocio-demographic index |
| spellingShingle | Hao Chen Chen Sang Jia Jia Shan Zheng Minzhen Wang Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities Scientific Reports Prostate cancer Smoking Old men Global burden of disease Disability-adjusted life years Socio-demographic index |
| title | Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities |
| title_full | Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities |
| title_fullStr | Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities |
| title_full_unstemmed | Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities |
| title_short | Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities |
| title_sort | severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities |
| topic | Prostate cancer Smoking Old men Global burden of disease Disability-adjusted life years Socio-demographic index |
| url | https://doi.org/10.1038/s41598-025-16160-9 |
| work_keys_str_mv | AT haochen severeandenduringprostatecancerburdenattributabletosmokingamongoldmenamidglobaldeclineandsocioeconomicdisparities AT chensang severeandenduringprostatecancerburdenattributabletosmokingamongoldmenamidglobaldeclineandsocioeconomicdisparities AT jiajia severeandenduringprostatecancerburdenattributabletosmokingamongoldmenamidglobaldeclineandsocioeconomicdisparities AT shanzheng severeandenduringprostatecancerburdenattributabletosmokingamongoldmenamidglobaldeclineandsocioeconomicdisparities AT minzhenwang severeandenduringprostatecancerburdenattributabletosmokingamongoldmenamidglobaldeclineandsocioeconomicdisparities |