A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid

A 76-year-old woman was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma by upper gastrointestinal endoscopy. She underwent further investigation for concomitant bilateral pleural effusions and right pulmonary consolidation. MALT lymphoma with the t(11; 18)(q21; q21) translocation an...

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Main Authors: Yusuke Nakamura, Akihiro Takemasa, Yuki Ohoka, Nobuhiko Tsukada, Azusa Tsukada, Yoshimasa Nakazato, Kinuko Mitani, Akihiko Toyoda, Yasuo Shimizu, Seiji Niho
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Respiratory Medicine Case Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213007124001564
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author Yusuke Nakamura
Akihiro Takemasa
Yuki Ohoka
Nobuhiko Tsukada
Azusa Tsukada
Yoshimasa Nakazato
Kinuko Mitani
Akihiko Toyoda
Yasuo Shimizu
Seiji Niho
author_facet Yusuke Nakamura
Akihiro Takemasa
Yuki Ohoka
Nobuhiko Tsukada
Azusa Tsukada
Yoshimasa Nakazato
Kinuko Mitani
Akihiko Toyoda
Yasuo Shimizu
Seiji Niho
author_sort Yusuke Nakamura
collection DOAJ
description A 76-year-old woman was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma by upper gastrointestinal endoscopy. She underwent further investigation for concomitant bilateral pleural effusions and right pulmonary consolidation. MALT lymphoma with the t(11; 18)(q21; q21) translocation and API2-MALT1 were detected in pleural fluid. Lymphoma was not histopathologically diagnosed by lung biopsies, but the same translocation was identified in bronchial lavage. MALT lymphoma is often difficult to diagnose by bronchoscopy because of only mild dysplasia. However, present report on using chromosomal translocation analysis from bronchial lavage indicates that such testing may serve as a useful diagnostic adjunct in MALT lymphoma with lung involvement.
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publishDate 2024-01-01
publisher Elsevier
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series Respiratory Medicine Case Reports
spelling doaj-art-89ec86c5f2334ebdb6516a539fbba17d2025-08-20T02:38:11ZengElsevierRespiratory Medicine Case Reports2213-00712024-01-015210213310.1016/j.rmcr.2024.102133A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluidYusuke Nakamura0Akihiro Takemasa1Yuki Ohoka2Nobuhiko Tsukada3Azusa Tsukada4Yoshimasa Nakazato5Kinuko Mitani6Akihiko Toyoda7Yasuo Shimizu8Seiji Niho9Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, JapanDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan; Respiratory endoscopy center, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan; Corresponding author. Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, JapanDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, JapanDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, JapanDepartment of Pathology, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara City, Tochigi, 324-8501, JapanDepartment of Hematology and Oncology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, JapanDepartment of Pathology, Kamitsuga General Hospital, 1-1033 Shimotamachi, Kanuma, Tochigi, 322-8550, JapanDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan; Respiratory endoscopy center, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, JapanDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, JapanA 76-year-old woman was diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma by upper gastrointestinal endoscopy. She underwent further investigation for concomitant bilateral pleural effusions and right pulmonary consolidation. MALT lymphoma with the t(11; 18)(q21; q21) translocation and API2-MALT1 were detected in pleural fluid. Lymphoma was not histopathologically diagnosed by lung biopsies, but the same translocation was identified in bronchial lavage. MALT lymphoma is often difficult to diagnose by bronchoscopy because of only mild dysplasia. However, present report on using chromosomal translocation analysis from bronchial lavage indicates that such testing may serve as a useful diagnostic adjunct in MALT lymphoma with lung involvement.http://www.sciencedirect.com/science/article/pii/S2213007124001564MALT lymphomat(1118)(q21q21)API2-MALT1 fusion geneBronchial lavage fluid
spellingShingle Yusuke Nakamura
Akihiro Takemasa
Yuki Ohoka
Nobuhiko Tsukada
Azusa Tsukada
Yoshimasa Nakazato
Kinuko Mitani
Akihiko Toyoda
Yasuo Shimizu
Seiji Niho
A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid
Respiratory Medicine Case Reports
MALT lymphoma
t(11
18)(q21
q21)
API2-MALT1 fusion gene
Bronchial lavage fluid
title A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid
title_full A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid
title_fullStr A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid
title_full_unstemmed A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid
title_short A case of pulmonary mucosa-associated lymphoid tissue lymphoma diagnosed by detecting t(11;18)(q21;q21) in bronchial lavage fluid
title_sort case of pulmonary mucosa associated lymphoid tissue lymphoma diagnosed by detecting t 11 18 q21 q21 in bronchial lavage fluid
topic MALT lymphoma
t(11
18)(q21
q21)
API2-MALT1 fusion gene
Bronchial lavage fluid
url http://www.sciencedirect.com/science/article/pii/S2213007124001564
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