Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users
Prolonged heavy exposure to cannabis is associated with impaired cognition and brain functional and structural alterations. We recently reported attenuated mismatch negativity (MMN) and altered P50 sensory gating in chronic cannabis users. This study investigated the extent of brain functional recov...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/6526437 |
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| author | Samantha J. Broyd Lisa-marie Greenwood Hendrika H. van Hell Rodney J. Croft Hannah Coyle Ben Lee-Bates Juanita Todd Stuart J. Johnstone Patricia T. Michie Nadia Solowij |
| author_facet | Samantha J. Broyd Lisa-marie Greenwood Hendrika H. van Hell Rodney J. Croft Hannah Coyle Ben Lee-Bates Juanita Todd Stuart J. Johnstone Patricia T. Michie Nadia Solowij |
| author_sort | Samantha J. Broyd |
| collection | DOAJ |
| description | Prolonged heavy exposure to cannabis is associated with impaired cognition and brain functional and structural alterations. We recently reported attenuated mismatch negativity (MMN) and altered P50 sensory gating in chronic cannabis users. This study investigated the extent of brain functional recovery (indexed by MMN and P50) in chronic users after cessation of use. Eighteen ex-users (median 13.5 years prior regular use; median 3.5 years abstinence) and 18 nonusers completed (1) a multifeature oddball task with duration, frequency, and intensity deviants and (2) a P50 paired-click paradigm. Trend level smaller duration MMN amplitude and larger P50 ratios (indicative of poorer sensory gating) were observed in ex-users compared to controls. Poorer P50 gating correlated with prior duration of cannabis use. Duration of abstinence was positively correlated with duration MMN amplitude, even after controlling for age and duration of cannabis use. Impaired sensory gating and attenuated MMN amplitude tended to persist in ex-users after prolonged cessation of use, suggesting a lack of full recovery. An association with prolonged duration of prior cannabis use may indicate persistent cannabis-related alterations to P50 sensory gating. Greater reductions in MMN amplitude with increasing abstinence (positive correlation) may be related to either self-medication or an accelerated aging process. |
| format | Article |
| id | doaj-art-89e1f9c3af4f448bb71792feba8b809b |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-89e1f9c3af4f448bb71792feba8b809b2025-08-20T03:37:50ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/65264376526437Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis UsersSamantha J. Broyd0Lisa-marie Greenwood1Hendrika H. van Hell2Rodney J. Croft3Hannah Coyle4Ben Lee-Bates5Juanita Todd6Stuart J. Johnstone7Patricia T. Michie8Nadia Solowij9School of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaSchool of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, NSW 2308, AustraliaSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaSchool of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, NSW 2308, AustraliaSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, AustraliaProlonged heavy exposure to cannabis is associated with impaired cognition and brain functional and structural alterations. We recently reported attenuated mismatch negativity (MMN) and altered P50 sensory gating in chronic cannabis users. This study investigated the extent of brain functional recovery (indexed by MMN and P50) in chronic users after cessation of use. Eighteen ex-users (median 13.5 years prior regular use; median 3.5 years abstinence) and 18 nonusers completed (1) a multifeature oddball task with duration, frequency, and intensity deviants and (2) a P50 paired-click paradigm. Trend level smaller duration MMN amplitude and larger P50 ratios (indicative of poorer sensory gating) were observed in ex-users compared to controls. Poorer P50 gating correlated with prior duration of cannabis use. Duration of abstinence was positively correlated with duration MMN amplitude, even after controlling for age and duration of cannabis use. Impaired sensory gating and attenuated MMN amplitude tended to persist in ex-users after prolonged cessation of use, suggesting a lack of full recovery. An association with prolonged duration of prior cannabis use may indicate persistent cannabis-related alterations to P50 sensory gating. Greater reductions in MMN amplitude with increasing abstinence (positive correlation) may be related to either self-medication or an accelerated aging process.http://dx.doi.org/10.1155/2016/6526437 |
| spellingShingle | Samantha J. Broyd Lisa-marie Greenwood Hendrika H. van Hell Rodney J. Croft Hannah Coyle Ben Lee-Bates Juanita Todd Stuart J. Johnstone Patricia T. Michie Nadia Solowij Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users Neural Plasticity |
| title | Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users |
| title_full | Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users |
| title_fullStr | Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users |
| title_full_unstemmed | Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users |
| title_short | Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users |
| title_sort | mismatch negativity and p50 sensory gating in abstinent former cannabis users |
| url | http://dx.doi.org/10.1155/2016/6526437 |
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