Rhythm Control in AF: Have We Reached the Last Frontier?
AF is a worldwide epidemic, affecting approximately 33 million people, and its rising prevalence is expected to account for increasing clinical and public health costs. AF is associated with an increased risk of MI, heart failure, stroke, dementia, chronic kidney disease and mortality. Preserving si...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2019-07-01
|
| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articles/rhythm-control-in-atrial-fibrillation |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850104233290891264 |
|---|---|
| author | Gheorghe-Andrei Dan |
| author_facet | Gheorghe-Andrei Dan |
| author_sort | Gheorghe-Andrei Dan |
| collection | DOAJ |
| description | AF is a worldwide epidemic, affecting approximately 33 million people, and its rising prevalence is expected to account for increasing clinical and public health costs. AF is associated with an increased risk of MI, heart failure, stroke, dementia, chronic kidney disease and mortality. Preserving sinus rhythm is essential for a better outcome. However, because of the inherent limits of both pharmacological and interventional methods, rhythm strategy management is reserved for symptom and quality-of-life improvement. While ‘classical’ antiarrhythmic drug therapy remains the first-line therapy for rhythm control, its efficacy and safety are limited by empirical use, proarrhythmic risk and organ toxicity. Ablative techniques have had an impressive development, but AF ablation still failed to demonstrate a significant impact on hard endpoints. Understanding of the complex mechanisms of AF will help to develop new vulnerable targets to therapy. Promising molecules are under development, intended to fill the gap between the current pharmacological treatment aimed at maintaining sinus rhythm and the expectations from rhythm strategy. |
| format | Article |
| id | doaj-art-89e0833035cd402797df4c1d51aaa7ef |
| institution | DOAJ |
| issn | 1758-3756 1758-3764 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj-art-89e0833035cd402797df4c1d51aaa7ef2025-08-20T02:39:22ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642019-07-01142778110.15420/ecr.2019.8.1Rhythm Control in AF: Have We Reached the Last Frontier?Gheorghe-Andrei Dan0Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Colentina University Hospital, Bucharest, RomaniaAF is a worldwide epidemic, affecting approximately 33 million people, and its rising prevalence is expected to account for increasing clinical and public health costs. AF is associated with an increased risk of MI, heart failure, stroke, dementia, chronic kidney disease and mortality. Preserving sinus rhythm is essential for a better outcome. However, because of the inherent limits of both pharmacological and interventional methods, rhythm strategy management is reserved for symptom and quality-of-life improvement. While ‘classical’ antiarrhythmic drug therapy remains the first-line therapy for rhythm control, its efficacy and safety are limited by empirical use, proarrhythmic risk and organ toxicity. Ablative techniques have had an impressive development, but AF ablation still failed to demonstrate a significant impact on hard endpoints. Understanding of the complex mechanisms of AF will help to develop new vulnerable targets to therapy. Promising molecules are under development, intended to fill the gap between the current pharmacological treatment aimed at maintaining sinus rhythm and the expectations from rhythm strategy.https://www.ecrjournal.com/articles/rhythm-control-in-atrial-fibrillation |
| spellingShingle | Gheorghe-Andrei Dan Rhythm Control in AF: Have We Reached the Last Frontier? European Cardiology Review |
| title | Rhythm Control in AF: Have We Reached the Last Frontier? |
| title_full | Rhythm Control in AF: Have We Reached the Last Frontier? |
| title_fullStr | Rhythm Control in AF: Have We Reached the Last Frontier? |
| title_full_unstemmed | Rhythm Control in AF: Have We Reached the Last Frontier? |
| title_short | Rhythm Control in AF: Have We Reached the Last Frontier? |
| title_sort | rhythm control in af have we reached the last frontier |
| url | https://www.ecrjournal.com/articles/rhythm-control-in-atrial-fibrillation |
| work_keys_str_mv | AT gheorgheandreidan rhythmcontrolinafhavewereachedthelastfrontier |