Translation of bi-directional transcripts enhances MHC-I peptide diversity

Antisense transcripts play an important role in generating regulatory non-coding RNAs but whether these transcripts are also translated to generate functional peptides remains poorly understood. In this study, RNA sequencing and six-frame database generation were combined with mass spectrometry anal...

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Main Authors: Filip Zavadil, Tomas Henek, Justine Habault, René Chemali, Maria Camila Tovar-Fernandez, Chrysoula Daskalogianni, Laurence Malbert-Colas, Lixiao Wang, Sivakumar Vadivel Gnanasundram, Borek Vojtesek, Lenka Hernychova, Sebastien Apcher, Robin Fahraeus
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554561/full
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