Neobractatin and Trametinib Synergistically Induce Apoptosis and Gasdermin E‐Dependent Pyroptosis in Pancreatic Cancer Cells

Neobractatin and Trametinib Synergistically Induce Apoptosis and Gasdermin E‐Dependent Pyroptosis in Pancreatic Cancer Cells

ABSTRACT Mutations in mitogen‐activated protein kinase kinase (MEK) are prevalent in pancreatic ductal adenocarcinoma (PDAC), but many MEK inhibitors inadvertently activate protein kinase B (AKT). We propose a promising PDAC treatment strategy by combining the MEK inhibitor trametinib with neobracta...

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Bibliographic Details
Main Authors: Jiaqi Tan, Ziyi Bao, Kai Qin, Liujing Zhu, Changwu Zheng, Jiabin Jin, Li Zhang, Hongxi Xu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:MedComm
Subjects:
AKT
gasdermin E
pancreatic ductal adenocarcinoma
pyroptosis
ROS
Online Access:https://doi.org/10.1002/mco2.70250
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