Super‐Enhancer Reprograming Driven by SOX9 and TCF7L2 Represents Transcription‐Targeted Therapeutic Vulnerability for Treating Gallbladder Cancer

Super‐Enhancer Reprograming Driven by SOX9 and TCF7L2 Represents Transcription‐Targeted Therapeutic Vulnerability for Treating Gallbladder Cancer

Abstract Gallbladder cancer (GBC) is a highly aggressive malignancy lacking clinically available targeted therapeutic agents. Super‐enhancers (SEs) are crucial epigenetic cis‐regulatory elements whose extensive reprogramming drives aberrant transcription in cancers. To study SE in GBC, the genomic d...

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Main Authors: Siyuan Yan, Zhaonan Liu, Teng Wang, Yi Sui, Xiangsong Wu, Jiayi Shen, Peng Pu, Yang Yang, Sizhong Wu, Shimei Qiu, Ziyi Wang, Xiaoqing Jiang, Feiling Feng, Guoqiang Li, FaTao Liu, Chaoxian Zhao, Ke Liu, Jiayi Feng, Maolan Li, Kwan Man, Chaochen Wang, Yujie Tang, Yingbin Liu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
core regulatory circuitry
gallbladder cancer
SOX9
super‐enhancer
TCF7L2
transcription‐targeted CDK7 inhibition therapy
Online Access:https://doi.org/10.1002/advs.202406448
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