Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobromines
The problem of searching biologically active compounds amidst xanthine derivatives is a crucial one and is an issue for long-term investigation. Aim. In order to find new biologically active compounds among xanthine derivatives, undescribed earlier 8-benzylidenhydrazino-1-p-methylbenzyltheobromin...
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Zaporizhzhia State Medical and Pharmaceutical University
2015-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/53768/50333 |
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| author | D. G. Ivanchenko |
| author_facet | D. G. Ivanchenko |
| author_sort | D. G. Ivanchenko |
| collection | DOAJ |
| description | The problem of searching biologically active compounds amidst xanthine derivatives is a crucial one and is an issue for long-term investigation.
Aim. In order to find new biologically active compounds among xanthine derivatives, undescribed earlier 8-benzylidenhydrazino-1-p-methylbenzyltheobromines have been synthesized.
Methods and results. Reaction of 1-p-methylbenzyl-8-bromoxanthine with the excess of hydrazine hydrate in the aqueous dioxane is implemented through formation of 8-hydrazine-1(4-methylbenzyl)theobromine. Through the interaction of 8-hydrazinetheobromine with aldehydes in aqueous propan-2-ol respective 8-benzylidenhydrazino-1-p-methylbenzyltheobromines have been obtained. Structure of synthesized compounds has been definitely proved by NMR-spectroscopy.
Conclusions. Molecular and pharmacological descriptors of obtained substances have been calculated. The antioxidant activity of the obtained compounds has been explored. Priorities for further search of biologically active compounds in a range of xanthine derivatives have been set out. |
| format | Article |
| id | doaj-art-89da6f8d04024347bb3cb4fefd49bc5c |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-89da6f8d04024347bb3cb4fefd49bc5c2025-08-20T01:58:12ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-10-0158992http://dx.doi.org/10.14739/2310-1210.2015.5.53768Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobrominesD. G. IvanchenkoThe problem of searching biologically active compounds amidst xanthine derivatives is a crucial one and is an issue for long-term investigation. Aim. In order to find new biologically active compounds among xanthine derivatives, undescribed earlier 8-benzylidenhydrazino-1-p-methylbenzyltheobromines have been synthesized. Methods and results. Reaction of 1-p-methylbenzyl-8-bromoxanthine with the excess of hydrazine hydrate in the aqueous dioxane is implemented through formation of 8-hydrazine-1(4-methylbenzyl)theobromine. Through the interaction of 8-hydrazinetheobromine with aldehydes in aqueous propan-2-ol respective 8-benzylidenhydrazino-1-p-methylbenzyltheobromines have been obtained. Structure of synthesized compounds has been definitely proved by NMR-spectroscopy. Conclusions. Molecular and pharmacological descriptors of obtained substances have been calculated. The antioxidant activity of the obtained compounds has been explored. Priorities for further search of biologically active compounds in a range of xanthine derivatives have been set out.http://zmj.zsmu.edu.ua/article/view/53768/50333XanthineOrganic SynthesisNMR-spectroscopyAcute ToxicityAntioxidant Effect |
| spellingShingle | D. G. Ivanchenko Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobromines Zaporožskij Medicinskij Žurnal Xanthine Organic Synthesis NMR-spectroscopy Acute Toxicity Antioxidant Effect |
| title | Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobromines |
| title_full | Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobromines |
| title_fullStr | Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobromines |
| title_full_unstemmed | Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobromines |
| title_short | Synthesis, physical-chemical and biological properties of 1.8-disubstituted of theobromine. V. 8-Benzylidenhydrazino-1-p-methylbenzyltheobromines |
| title_sort | synthesis physical chemical and biological properties of 1 8 disubstituted of theobromine v 8 benzylidenhydrazino 1 p methylbenzyltheobromines |
| topic | Xanthine Organic Synthesis NMR-spectroscopy Acute Toxicity Antioxidant Effect |
| url | http://zmj.zsmu.edu.ua/article/view/53768/50333 |
| work_keys_str_mv | AT dgivanchenko synthesisphysicalchemicalandbiologicalpropertiesof18disubstitutedoftheobrominev8benzylidenhydrazino1pmethylbenzyltheobromines |