Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases
Objective To preliminarily investigate the relationship between the expression of wnt4 and β-catenin in the renal glomerulonephritis tissue and renal tubular injury and renal interstitial fibrosis. Methods A total of 56 patients with primary glomerulonephritis and renal biopsy were enrolled in the s...
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Editorial Department of Journal of Clinical Nephrology
2019-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | WU Xiao-zhen LIU Gang LIU Man TAO Lin JIANG Jin-fang YANG Xiao-ping |
| author_facet | WU Xiao-zhen LIU Gang LIU Man TAO Lin JIANG Jin-fang YANG Xiao-ping |
| author_sort | WU Xiao-zhen |
| collection | DOAJ |
| description | Objective To preliminarily investigate the relationship between the expression of wnt4 and β-catenin in the renal glomerulonephritis tissue and renal tubular injury and renal interstitial fibrosis. Methods A total of 56 patients with primary glomerulonephritis and renal biopsy were enrolled in the study. According to tubulointerstitial injury scores, the patients were divided into mild injury group(n=22), moderate injury group(n=18) and severe injury group(n=16), and another 10 patients with normal renal tissues(all from excised normal renal tissues of patients with renal tumor) were chosen as the control group. Immunohistochemistry was used to detect wnt4 and β-catenin in renal tissues in each group. The related clinical indicators were determined at the same time to analyze the relationship between the changes of wnt4 and β-catenin levels and clinical characteristics of the patients. Results Immunohistochemistry showed that, wnt4 and β-catenin were not expressed in renal tissues in the normal control group, but were notably expressed in renal tissues of patients with glomerulonephritis. With the severity of renal interstitial fibrosis, the expression levels of wnt4 and β-catenin exhibited an increasing trend(P<0.05). The expression level of wnt4 in epithelial cells in the renal tubules exhibited positive correlation with β2-microglobin(r=0.29, P<0.05), and negative correlation with eGFR(r=-0.38, P<0.05). Conclusions The expression levels of wnt4 and β-catenin in renal tissue of patients with primary glomerulonephritis with renal interstitial fibrosis are consistent, are both higher than those in normal renal tissue without fibrosis. The wnt4/β-catenin signaling pathway may be involved in the progression of tubulointerstitial fibrosis in glomerulonephritis. |
| format | Article |
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| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2019-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-89d5a69da2ca4ee6afd155bc30328e9e2025-08-20T02:28:51ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902019-01-011952052457911682Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseasesWU Xiao-zhenLIU GangLIU ManTAO LinJIANG Jin-fangYANG Xiao-pingObjective To preliminarily investigate the relationship between the expression of wnt4 and β-catenin in the renal glomerulonephritis tissue and renal tubular injury and renal interstitial fibrosis. Methods A total of 56 patients with primary glomerulonephritis and renal biopsy were enrolled in the study. According to tubulointerstitial injury scores, the patients were divided into mild injury group(n=22), moderate injury group(n=18) and severe injury group(n=16), and another 10 patients with normal renal tissues(all from excised normal renal tissues of patients with renal tumor) were chosen as the control group. Immunohistochemistry was used to detect wnt4 and β-catenin in renal tissues in each group. The related clinical indicators were determined at the same time to analyze the relationship between the changes of wnt4 and β-catenin levels and clinical characteristics of the patients. Results Immunohistochemistry showed that, wnt4 and β-catenin were not expressed in renal tissues in the normal control group, but were notably expressed in renal tissues of patients with glomerulonephritis. With the severity of renal interstitial fibrosis, the expression levels of wnt4 and β-catenin exhibited an increasing trend(P<0.05). The expression level of wnt4 in epithelial cells in the renal tubules exhibited positive correlation with β2-microglobin(r=0.29, P<0.05), and negative correlation with eGFR(r=-0.38, P<0.05). Conclusions The expression levels of wnt4 and β-catenin in renal tissue of patients with primary glomerulonephritis with renal interstitial fibrosis are consistent, are both higher than those in normal renal tissue without fibrosis. The wnt4/β-catenin signaling pathway may be involved in the progression of tubulointerstitial fibrosis in glomerulonephritis.http://www.lcszb.com/thesisDetails?columnId=57911682&Fpath=home&index=0Wnt4β-cateninPrimary glomerulonephritisRenal interstitial fibrosis |
| spellingShingle | WU Xiao-zhen LIU Gang LIU Man TAO Lin JIANG Jin-fang YANG Xiao-ping Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases Linchuang shenzangbing zazhi Wnt4 β-catenin Primary glomerulonephritis Renal interstitial fibrosis |
| title | Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases |
| title_full | Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases |
| title_fullStr | Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases |
| title_full_unstemmed | Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases |
| title_short | Expression and clinical significance of Wnt4/β-catenin signaling pathway in glomerular diseases |
| title_sort | expression and clinical significance of wnt4 β catenin signaling pathway in glomerular diseases |
| topic | Wnt4 β-catenin Primary glomerulonephritis Renal interstitial fibrosis |
| url | http://www.lcszb.com/thesisDetails?columnId=57911682&Fpath=home&index=0 |
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