Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in Indonesia
Context: Tuberculosis (TB) is a significant problem among children in Indonesia. While pulmonary TB has been widely reported, information on extrapulmonary TB (EPTB) among children in Indonesia has not been well documented. Aims: The aim of this study is to document demographic and clinical characte...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-07-01
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| Series: | Pediatric Respirology and Critical Care Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/prcm.prcm_10_18 |
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| author | Rina Triasih Riana Helmi Ida Safitri Laksanawati |
| author_facet | Rina Triasih Riana Helmi Ida Safitri Laksanawati |
| author_sort | Rina Triasih |
| collection | DOAJ |
| description | Context:
Tuberculosis (TB) is a significant problem among children in Indonesia. While pulmonary TB has been widely reported, information on extrapulmonary TB (EPTB) among children in Indonesia has not been well documented.
Aims:
The aim of this study is to document demographic and clinical characteristics and outcome of EPTB in children.
Settings and Design:
A retrospective study was conducted in Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Subjects and Methods:
Medical records were reviewed for all children aged younger than 18 years diagnosed with EPTB and admitted to this hospital between 2009 and 2015.
Results:
Fifty-three patients with EPTB were admitted to the hospital during the study period. EPTB was more common in children aged >5 years, with median (interquartile range) age of presentation at 12.5 years (4.1–14.7 years). Major presenting symptoms were fever (72%), cough (55%), and weight loss (38%). Common types of EPTB were meningitis (28%), miliary TB (23%), and osteoarthritis (20%). The diagnosis was confirmed by either acid-fast bacilli smear or GeneXpert MTB/rifampicin (RIF) in 13 patients. Evidence of TB infection was documented in 26 % of children with positive result of tuberculin skin test. Mycobacterium TB was detected by GeneXpert MTB/RIF in 23% of children. The mortality rate was 19% which mostly occured in children with meningitis (60%).
Conclusion:
EPTB was commonly seen in older children, and tuberculous meningitis was both the most common type and cause of death of EPTB in our setting. |
| format | Article |
| id | doaj-art-89d44b2ddf97444d9491717e14bc686f |
| institution | DOAJ |
| issn | 2543-0343 2543-0351 |
| language | English |
| publishDate | 2018-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Pediatric Respirology and Critical Care Medicine |
| spelling | doaj-art-89d44b2ddf97444d9491717e14bc686f2025-08-20T03:13:42ZengWolters Kluwer Medknow PublicationsPediatric Respirology and Critical Care Medicine2543-03432543-03512018-07-0123515510.4103/prcm.prcm_10_18Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in IndonesiaRina TriasihRiana HelmiIda Safitri LaksanawatiContext: Tuberculosis (TB) is a significant problem among children in Indonesia. While pulmonary TB has been widely reported, information on extrapulmonary TB (EPTB) among children in Indonesia has not been well documented. Aims: The aim of this study is to document demographic and clinical characteristics and outcome of EPTB in children. Settings and Design: A retrospective study was conducted in Dr. Sardjito Hospital, Yogyakarta, Indonesia. Subjects and Methods: Medical records were reviewed for all children aged younger than 18 years diagnosed with EPTB and admitted to this hospital between 2009 and 2015. Results: Fifty-three patients with EPTB were admitted to the hospital during the study period. EPTB was more common in children aged >5 years, with median (interquartile range) age of presentation at 12.5 years (4.1–14.7 years). Major presenting symptoms were fever (72%), cough (55%), and weight loss (38%). Common types of EPTB were meningitis (28%), miliary TB (23%), and osteoarthritis (20%). The diagnosis was confirmed by either acid-fast bacilli smear or GeneXpert MTB/rifampicin (RIF) in 13 patients. Evidence of TB infection was documented in 26 % of children with positive result of tuberculin skin test. Mycobacterium TB was detected by GeneXpert MTB/RIF in 23% of children. The mortality rate was 19% which mostly occured in children with meningitis (60%). Conclusion: EPTB was commonly seen in older children, and tuberculous meningitis was both the most common type and cause of death of EPTB in our setting.https://journals.lww.com/10.4103/prcm.prcm_10_18characteristicchildextrapulmonary tuberculosisoutcome |
| spellingShingle | Rina Triasih Riana Helmi Ida Safitri Laksanawati Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in Indonesia Pediatric Respirology and Critical Care Medicine characteristic child extrapulmonary tuberculosis outcome |
| title | Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in Indonesia |
| title_full | Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in Indonesia |
| title_fullStr | Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in Indonesia |
| title_full_unstemmed | Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in Indonesia |
| title_short | Clinical Profile and Outcome of Extrapulmonary Tuberculosis in Children in Indonesia |
| title_sort | clinical profile and outcome of extrapulmonary tuberculosis in children in indonesia |
| topic | characteristic child extrapulmonary tuberculosis outcome |
| url | https://journals.lww.com/10.4103/prcm.prcm_10_18 |
| work_keys_str_mv | AT rinatriasih clinicalprofileandoutcomeofextrapulmonarytuberculosisinchildreninindonesia AT rianahelmi clinicalprofileandoutcomeofextrapulmonarytuberculosisinchildreninindonesia AT idasafitrilaksanawati clinicalprofileandoutcomeofextrapulmonarytuberculosisinchildreninindonesia |