Primary Intracranial Synovial Sarcoma
Background. Synovial sarcoma is an aggressive soft tissue sarcoma with uncertain histological origin. The pathology frequently presents as a localized disease, especially near large joints around the knee and thigh. Intracranial disease, which is rare, has been reported as metastasis from synovial s...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/5608315 |
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| author | Mohit Patel Luyuan Li Ha Son Nguyen Ninh Doan Grant Sinson Wade Mueller |
| author_facet | Mohit Patel Luyuan Li Ha Son Nguyen Ninh Doan Grant Sinson Wade Mueller |
| author_sort | Mohit Patel |
| collection | DOAJ |
| description | Background. Synovial sarcoma is an aggressive soft tissue sarcoma with uncertain histological origin. The pathology frequently presents as a localized disease, especially near large joints around the knee and thigh. Intracranial disease, which is rare, has been reported as metastasis from synovial sarcoma. We report a case with no obvious primary extracranial pathology, suggesting primary intracranial disease; this has not been reported in the literature. Case Description. A 21-year-old male, with a prior right skull lesion resection for atypical spindle cell neoplasm, presented with headaches, gait instability, left arm weakness, and left homonymous hemianopsia. CT of head demonstrated a right parietal hemorrhagic lesion with mass effect, requiring surgical decompression. Histopathology revealed synovial sarcoma. FISH analysis noted the existence of the t(X;18)(p11.2;q11.2) chromosomal translocation. PET scan did not show other metastatic disease. He underwent stereotactic radiotherapy and adjuvant chemotherapy. At 2-year follow-up, he remained nonfocal without recurrence. Conclusion. We report the first known case of primary intracranial synovial sarcoma. Moreover, we stress that intracranial lesions may have a tendency for hemorrhage, requiring urgent lifesaving decompression. |
| format | Article |
| id | doaj-art-89d3c743315440b1b8a78fb3971e57d9 |
| institution | OA Journals |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-89d3c743315440b1b8a78fb3971e57d92025-08-20T02:09:19ZengWileyCase Reports in Neurological Medicine2090-66682090-66762016-01-01201610.1155/2016/56083155608315Primary Intracranial Synovial SarcomaMohit Patel0Luyuan Li1Ha Son Nguyen2Ninh Doan3Grant Sinson4Wade Mueller5Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USADepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USABackground. Synovial sarcoma is an aggressive soft tissue sarcoma with uncertain histological origin. The pathology frequently presents as a localized disease, especially near large joints around the knee and thigh. Intracranial disease, which is rare, has been reported as metastasis from synovial sarcoma. We report a case with no obvious primary extracranial pathology, suggesting primary intracranial disease; this has not been reported in the literature. Case Description. A 21-year-old male, with a prior right skull lesion resection for atypical spindle cell neoplasm, presented with headaches, gait instability, left arm weakness, and left homonymous hemianopsia. CT of head demonstrated a right parietal hemorrhagic lesion with mass effect, requiring surgical decompression. Histopathology revealed synovial sarcoma. FISH analysis noted the existence of the t(X;18)(p11.2;q11.2) chromosomal translocation. PET scan did not show other metastatic disease. He underwent stereotactic radiotherapy and adjuvant chemotherapy. At 2-year follow-up, he remained nonfocal without recurrence. Conclusion. We report the first known case of primary intracranial synovial sarcoma. Moreover, we stress that intracranial lesions may have a tendency for hemorrhage, requiring urgent lifesaving decompression.http://dx.doi.org/10.1155/2016/5608315 |
| spellingShingle | Mohit Patel Luyuan Li Ha Son Nguyen Ninh Doan Grant Sinson Wade Mueller Primary Intracranial Synovial Sarcoma Case Reports in Neurological Medicine |
| title | Primary Intracranial Synovial Sarcoma |
| title_full | Primary Intracranial Synovial Sarcoma |
| title_fullStr | Primary Intracranial Synovial Sarcoma |
| title_full_unstemmed | Primary Intracranial Synovial Sarcoma |
| title_short | Primary Intracranial Synovial Sarcoma |
| title_sort | primary intracranial synovial sarcoma |
| url | http://dx.doi.org/10.1155/2016/5608315 |
| work_keys_str_mv | AT mohitpatel primaryintracranialsynovialsarcoma AT luyuanli primaryintracranialsynovialsarcoma AT hasonnguyen primaryintracranialsynovialsarcoma AT ninhdoan primaryintracranialsynovialsarcoma AT grantsinson primaryintracranialsynovialsarcoma AT wademueller primaryintracranialsynovialsarcoma |