The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic
Abstract Background Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19. Objective This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the b...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Psicologia: Reflexão e Crítica |
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| Online Access: | https://doi.org/10.1186/s41155-024-00335-w |
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| author | Dong Wang Haijin Li Yansong Liu Hong Li Yangyang Liu Lijun Hou |
| author_facet | Dong Wang Haijin Li Yansong Liu Hong Li Yangyang Liu Lijun Hou |
| author_sort | Dong Wang |
| collection | DOAJ |
| description | Abstract Background Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19. Objective This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19. Methods: A total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1β, IL-2, IL-6, IL-8, TNF-a, and IFN-γ, along with GDNF, were evaluated. Results Spearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (Spearman’s rho = .230, p = .021), obsessive–compulsive symptoms (Spearman’s rho = .201, p = .042). The levels of IL-8 were negatively associated with the anxiety score (Spearman’s rho = -.223, p = .028), obsessive–compulsive symptoms (Spearman’s rho = -.252, p = .012), hyperarousal (Spearman’s rho = -.221, p = .028). The levels of TNF-α were positively associated with the anxiety score (Spearman’s rho = .201, p = .045), obsessive–compulsive symptoms (Spearman’s rho = .222, p = .035). Conclusion Generally, our results suggested that IL-6, IL-8 and TNF-α might play a role in the development of psychological symptoms among medical staff. |
| format | Article |
| id | doaj-art-89d2f0836d3846d5baffe8abaad27b74 |
| institution | Kabale University |
| issn | 1678-7153 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Psicologia: Reflexão e Crítica |
| spelling | doaj-art-89d2f0836d3846d5baffe8abaad27b742025-01-12T12:36:43ZengSpringerOpenPsicologia: Reflexão e Crítica1678-71532025-01-013811810.1186/s41155-024-00335-wThe impact of inflammatory response on psychological status of medical staff during COVID-19 pandemicDong Wang0Haijin Li1Yansong Liu2Hong Li3Yangyang Liu4Lijun Hou5Department of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow UniversityDepartment of Psychiatry, the First Affiliated Hospital of Zhengzhou UniversityDepartment of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow UniversityDepartment of Psychiatry, the First Affiliated Hospital of Zhengzhou UniversityFirst People’s Hospital of Guannan CountyThe Affiliated Infectious Hospital of Soochow UniversityAbstract Background Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19. Objective This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19. Methods: A total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1β, IL-2, IL-6, IL-8, TNF-a, and IFN-γ, along with GDNF, were evaluated. Results Spearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (Spearman’s rho = .230, p = .021), obsessive–compulsive symptoms (Spearman’s rho = .201, p = .042). The levels of IL-8 were negatively associated with the anxiety score (Spearman’s rho = -.223, p = .028), obsessive–compulsive symptoms (Spearman’s rho = -.252, p = .012), hyperarousal (Spearman’s rho = -.221, p = .028). The levels of TNF-α were positively associated with the anxiety score (Spearman’s rho = .201, p = .045), obsessive–compulsive symptoms (Spearman’s rho = .222, p = .035). Conclusion Generally, our results suggested that IL-6, IL-8 and TNF-α might play a role in the development of psychological symptoms among medical staff.https://doi.org/10.1186/s41155-024-00335-wPsychological statusInflammatory parametersPsychopathologySCL-90COVID-19 |
| spellingShingle | Dong Wang Haijin Li Yansong Liu Hong Li Yangyang Liu Lijun Hou The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic Psicologia: Reflexão e Crítica Psychological status Inflammatory parameters Psychopathology SCL-90 COVID-19 |
| title | The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic |
| title_full | The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic |
| title_fullStr | The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic |
| title_full_unstemmed | The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic |
| title_short | The impact of inflammatory response on psychological status of medical staff during COVID-19 pandemic |
| title_sort | impact of inflammatory response on psychological status of medical staff during covid 19 pandemic |
| topic | Psychological status Inflammatory parameters Psychopathology SCL-90 COVID-19 |
| url | https://doi.org/10.1186/s41155-024-00335-w |
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