Association between periodontal disease and Alzheimer's disease: umbrella review
BackgroundAlzheimer's disease (AD) and periodontal disease (PD) are both chronic conditions with rising global prevalence. Emerging research suggests a possible link between PD-induced systemic inflammation and neurodegeneration observed in AD.ObjectiveEmploy an umbrella review to look into the...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Dental Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2025.1635200/full |
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| author | Heber Isac Arbildo-Vega Heber Isac Arbildo-Vega Fredy Hugo Cruzado-Oliva Franz Tito Coronel-Zubiate Rubén Aguirre-Ipenza Joan Manuel Meza-Málaga Joan Manuel Meza-Málaga Sara Antonieta Luján-Valencia Sara Antonieta Luján-Valencia Eduardo Luján-Urviola Adriana Echevarria-Goche Carlos Alberto Farje-Gallardo Tania Belú Castillo-Cornock Tania Belú Castillo-Cornock Katherine Serquen-Olano Katherine Serquen-Olano Tania Padilla-Cáceres Tania Padilla-Cáceres Luz Caballero-Apaza |
| author_facet | Heber Isac Arbildo-Vega Heber Isac Arbildo-Vega Fredy Hugo Cruzado-Oliva Franz Tito Coronel-Zubiate Rubén Aguirre-Ipenza Joan Manuel Meza-Málaga Joan Manuel Meza-Málaga Sara Antonieta Luján-Valencia Sara Antonieta Luján-Valencia Eduardo Luján-Urviola Adriana Echevarria-Goche Carlos Alberto Farje-Gallardo Tania Belú Castillo-Cornock Tania Belú Castillo-Cornock Katherine Serquen-Olano Katherine Serquen-Olano Tania Padilla-Cáceres Tania Padilla-Cáceres Luz Caballero-Apaza |
| author_sort | Heber Isac Arbildo-Vega |
| collection | DOAJ |
| description | BackgroundAlzheimer's disease (AD) and periodontal disease (PD) are both chronic conditions with rising global prevalence. Emerging research suggests a possible link between PD-induced systemic inflammation and neurodegeneration observed in AD.ObjectiveEmploy an umbrella review to look into the association between periodontal disease and Alzheimer's disease.Materials and methodsA comprehensive search was conducted until March 2025 across various electronic databases, including: PubMed, Cochrane Library, Scopus, SciELO, Web of Science, Google Scholar, ProQuest, and OpenGrey, and Dissertations and Theses. There were no time or language restrictions on the inclusion of systematic reviews (SR), with or without meta-analysis, as long as they looked at primary research that connected PD and AD. The following were excluded: preclinical and fundamental research, summaries, comments, case reports, protocols, personal opinions, letters, posters, literary or narrative reviews, fast reviews, intervention studies, and observational studies. The quality and general confidence of the included studies were evaluated using the AMSTAR-2 technique.ResultsA total of 358 items were found following the first search. 16 articles were left for additional review after the selection criteria were applied. With odds ratios (OR) and risk ratios (RR) ranging from 1.67 to 2.17 and 1.11 to 2.26, respectively, 14 studies showed a correlation between PD and AD.ConclusionsDrawing from the findings and conclusions of the SR demonstrating a high overall confidence, it's established that PD and tooth loss exhibit an association with AD.Systematic Review RegistrationRegistered in the Open Science Framework (OSF): DOI 10.17605/OSF.IO/GS367. |
| format | Article |
| id | doaj-art-89d25f3225104502bc880cc796d7d2d7 |
| institution | DOAJ |
| issn | 2673-4915 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj-art-89d25f3225104502bc880cc796d7d2d72025-08-20T02:41:32ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152025-07-01610.3389/fdmed.2025.16352001635200Association between periodontal disease and Alzheimer's disease: umbrella reviewHeber Isac Arbildo-Vega0Heber Isac Arbildo-Vega1Fredy Hugo Cruzado-Oliva2Franz Tito Coronel-Zubiate3Rubén Aguirre-Ipenza4Joan Manuel Meza-Málaga5Joan Manuel Meza-Málaga6Sara Antonieta Luján-Valencia7Sara Antonieta Luján-Valencia8Eduardo Luján-Urviola9Adriana Echevarria-Goche10Carlos Alberto Farje-Gallardo11Tania Belú Castillo-Cornock12Tania Belú Castillo-Cornock13Katherine Serquen-Olano14Katherine Serquen-Olano15Tania Padilla-Cáceres16Tania Padilla-Cáceres17Luz Caballero-Apaza18Faculty of Dentistry, Dentistry School, Universidad San Martin de Porres, Chiclayo, PeruFaculty of Human Medicine, Human Medicine School, Universidad San Martín de Porres, Chiclayo, PeruFaculty of Stomatology, Stomatology School, Universidad Nacional de Trujillo, Trujillo, PeruFaculty of Health Sciences, Stomatology School, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, PeruFaculty of Health Sciences, Universidad Continental, Lima, PeruFaculty of Dentistry, Dentistry School, Universidad Católica de Santa María, Arequipa, PeruFaculty of Medicine, Medicine School, Universidad Católica de Santa María, Arequipa, PeruFaculty of Dentistry, Dentistry School, Universidad Católica de Santa María, Arequipa, PeruPostgraduate School, Universidad Católica de Santa María, Arequipa, PeruFaculty of Dentistry, Universidad Andina Néstor Cáceres Velásquez, Juliaca, Peru0Department of Dentistry, Dentistry School, Universidad Norbert Wiener, Lima, PeruFaculty of Health Sciences, Stomatology School, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, PeruFaculty of Dentistry, Dentistry School, Universidad San Martin de Porres, Chiclayo, Peru1Faculty of Health Sciences, Stomatology School, Universidad Señor de Sipán, Chiclayo, PeruFaculty of Dentistry, Dentistry School, Universidad San Martin de Porres, Chiclayo, Peru1Faculty of Health Sciences, Stomatology School, Universidad Señor de Sipán, Chiclayo, Peru2Department of General Dentistry, Dentistry School, Universidad del Altiplano, Puno, Peru3Research Institute in Environmental Sciences, Health and Biodiversity - IICASB, Universidad del Altiplano, Puno, Peru4Department of Nursing, School of Nursing, Universidad del Altiplano, Puno, PeruBackgroundAlzheimer's disease (AD) and periodontal disease (PD) are both chronic conditions with rising global prevalence. Emerging research suggests a possible link between PD-induced systemic inflammation and neurodegeneration observed in AD.ObjectiveEmploy an umbrella review to look into the association between periodontal disease and Alzheimer's disease.Materials and methodsA comprehensive search was conducted until March 2025 across various electronic databases, including: PubMed, Cochrane Library, Scopus, SciELO, Web of Science, Google Scholar, ProQuest, and OpenGrey, and Dissertations and Theses. There were no time or language restrictions on the inclusion of systematic reviews (SR), with or without meta-analysis, as long as they looked at primary research that connected PD and AD. The following were excluded: preclinical and fundamental research, summaries, comments, case reports, protocols, personal opinions, letters, posters, literary or narrative reviews, fast reviews, intervention studies, and observational studies. The quality and general confidence of the included studies were evaluated using the AMSTAR-2 technique.ResultsA total of 358 items were found following the first search. 16 articles were left for additional review after the selection criteria were applied. With odds ratios (OR) and risk ratios (RR) ranging from 1.67 to 2.17 and 1.11 to 2.26, respectively, 14 studies showed a correlation between PD and AD.ConclusionsDrawing from the findings and conclusions of the SR demonstrating a high overall confidence, it's established that PD and tooth loss exhibit an association with AD.Systematic Review RegistrationRegistered in the Open Science Framework (OSF): DOI 10.17605/OSF.IO/GS367.https://www.frontiersin.org/articles/10.3389/fdmed.2025.1635200/fullAlzheimer's diseaseperiodontal diseasetooth lossperiodontitisreview |
| spellingShingle | Heber Isac Arbildo-Vega Heber Isac Arbildo-Vega Fredy Hugo Cruzado-Oliva Franz Tito Coronel-Zubiate Rubén Aguirre-Ipenza Joan Manuel Meza-Málaga Joan Manuel Meza-Málaga Sara Antonieta Luján-Valencia Sara Antonieta Luján-Valencia Eduardo Luján-Urviola Adriana Echevarria-Goche Carlos Alberto Farje-Gallardo Tania Belú Castillo-Cornock Tania Belú Castillo-Cornock Katherine Serquen-Olano Katherine Serquen-Olano Tania Padilla-Cáceres Tania Padilla-Cáceres Luz Caballero-Apaza Association between periodontal disease and Alzheimer's disease: umbrella review Frontiers in Dental Medicine Alzheimer's disease periodontal disease tooth loss periodontitis review |
| title | Association between periodontal disease and Alzheimer's disease: umbrella review |
| title_full | Association between periodontal disease and Alzheimer's disease: umbrella review |
| title_fullStr | Association between periodontal disease and Alzheimer's disease: umbrella review |
| title_full_unstemmed | Association between periodontal disease and Alzheimer's disease: umbrella review |
| title_short | Association between periodontal disease and Alzheimer's disease: umbrella review |
| title_sort | association between periodontal disease and alzheimer s disease umbrella review |
| topic | Alzheimer's disease periodontal disease tooth loss periodontitis review |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2025.1635200/full |
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