Hepatoblastomas exhibit marked downregulation driven by promoter DNA hypermethylation

Hepatoblastomas exhibit marked downregulation driven by promoter DNA hypermethylation

Hepatoblastomas exhibit the lowest mutational burden among pediatric tumors. We previously showed that epigenetic disruption is crucial for hepatoblastoma carcinogenesis. Our data revealed hypermethylation of nicotinamide N-methyltransferase, a highly expressed gene in adipocytes and hepatocytes. Th...

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Main Authors: Maria Prates Rivas, Talita Ferreira Marques Aguiar, Mariana Maschietto, Renan B Lemes, Luiz Carlos Caires-Júnior, Ernesto Goulart, Kayque Alves Telles-Silva, Estela Novak, Lilian Maria Cristofani, Vicente Odone, Monica Cypriano, Silvia Regina Caminada de Toledo, Dirce Maria Carraro, Melissa Quintero Escobar, Hana Lee, Michael Johnston, Cecilia Maria Lima da Costa, Isabela Werneck da Cunha, Ljubica Tasic, Peter L Pearson, Carla Rosenberg, Nikolai Timchenko, Ana Cristina Victorino Krepischi
Format: Article
Language:English
Published: SAGE Publishing 2020-12-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428320977124
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