Transportation engineering for enhanced production of plant natural products in microbial cell factories
Plant natural products (PNPs) exhibit a wide range of biological activities and have essential applications in various fields such as medicine, agriculture, and flavors. Given their natural limitations, the production of high-value PNPs using microbial cell factories has become an effective alternat...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Synthetic and Systems Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405805X24000899 |
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| author | Yimeng Zuo Minghui Zhao Yuanwei Gou Lei Huang Zhinan Xu Jiazhang Lian |
| author_facet | Yimeng Zuo Minghui Zhao Yuanwei Gou Lei Huang Zhinan Xu Jiazhang Lian |
| author_sort | Yimeng Zuo |
| collection | DOAJ |
| description | Plant natural products (PNPs) exhibit a wide range of biological activities and have essential applications in various fields such as medicine, agriculture, and flavors. Given their natural limitations, the production of high-value PNPs using microbial cell factories has become an effective alternative in recent years. However, host metabolic burden caused by its massive accumulation has become one of the main challenges for efficient PNP production. Therefore, it is necessary to strengthen the transmembrane transport process of PNPs. This review introduces the discovery and mining of PNP transporters to directly mediate PNP transmembrane transportation both intracellularly and extracellularly. In addition to transporter engineering, this review also summarizes several auxiliary strategies (such as small molecules, environmental changes, and vesicles assisted transport) for strengthening PNP transportation. Finally, this review is concluded with the applications and future perspectives of transportation engineering in the construction and optimization of PNP microbial cell factories. |
| format | Article |
| id | doaj-art-89cdd451f9984554919a3d0dbddd36d1 |
| institution | Kabale University |
| issn | 2405-805X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Synthetic and Systems Biotechnology |
| spelling | doaj-art-89cdd451f9984554919a3d0dbddd36d12024-12-15T06:16:03ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2024-12-0194742751Transportation engineering for enhanced production of plant natural products in microbial cell factoriesYimeng Zuo0Minghui Zhao1Yuanwei Gou2Lei Huang3Zhinan Xu4Jiazhang Lian5Key Laboratory of Biomass Chemical Engineering of Ministry of Education & National Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310000, ChinaKey Laboratory of Biomass Chemical Engineering of Ministry of Education & National Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310000, ChinaKey Laboratory of Biomass Chemical Engineering of Ministry of Education & National Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310000, ChinaKey Laboratory of Biomass Chemical Engineering of Ministry of Education & National Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310000, China; Corresponding author.Key Laboratory of Biomass Chemical Engineering of Ministry of Education & National Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, ChinaKey Laboratory of Biomass Chemical Engineering of Ministry of Education & National Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310000, China; Corresponding author.Key Laboratory of Biomass Chemical Engineering of Ministry of Education & National Key Laboratory of Biobased Transportation Fuel Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, ChinaPlant natural products (PNPs) exhibit a wide range of biological activities and have essential applications in various fields such as medicine, agriculture, and flavors. Given their natural limitations, the production of high-value PNPs using microbial cell factories has become an effective alternative in recent years. However, host metabolic burden caused by its massive accumulation has become one of the main challenges for efficient PNP production. Therefore, it is necessary to strengthen the transmembrane transport process of PNPs. This review introduces the discovery and mining of PNP transporters to directly mediate PNP transmembrane transportation both intracellularly and extracellularly. In addition to transporter engineering, this review also summarizes several auxiliary strategies (such as small molecules, environmental changes, and vesicles assisted transport) for strengthening PNP transportation. Finally, this review is concluded with the applications and future perspectives of transportation engineering in the construction and optimization of PNP microbial cell factories.http://www.sciencedirect.com/science/article/pii/S2405805X24000899Plant natural productsTransportation engineeringTransportersMicrobial cell factories |
| spellingShingle | Yimeng Zuo Minghui Zhao Yuanwei Gou Lei Huang Zhinan Xu Jiazhang Lian Transportation engineering for enhanced production of plant natural products in microbial cell factories Synthetic and Systems Biotechnology Plant natural products Transportation engineering Transporters Microbial cell factories |
| title | Transportation engineering for enhanced production of plant natural products in microbial cell factories |
| title_full | Transportation engineering for enhanced production of plant natural products in microbial cell factories |
| title_fullStr | Transportation engineering for enhanced production of plant natural products in microbial cell factories |
| title_full_unstemmed | Transportation engineering for enhanced production of plant natural products in microbial cell factories |
| title_short | Transportation engineering for enhanced production of plant natural products in microbial cell factories |
| title_sort | transportation engineering for enhanced production of plant natural products in microbial cell factories |
| topic | Plant natural products Transportation engineering Transporters Microbial cell factories |
| url | http://www.sciencedirect.com/science/article/pii/S2405805X24000899 |
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