Mast Cells, Cytokines and Asthma
The appreciation that asthma is a chronic inflammatory disorder of the airways has led to a reappraisal of the importance of different cell populations within the bronchial mucosa with respect to their role in the regulation of the cellular events in this disease. While mast cell degranulation has b...
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/1994/435781 |
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| _version_ | 1849401026537324544 |
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| author | Anthony E Redington Peter H Howarth |
| author_facet | Anthony E Redington Peter H Howarth |
| author_sort | Anthony E Redington |
| collection | DOAJ |
| description | The appreciation that asthma is a chronic inflammatory
disorder of the airways has led to a reappraisal of the
importance of different cell populations within the bronchial
mucosa with respect to their role in the regulation of
the cellular events in this disease. While mast cell degranulation
has been implicated in the acute allergic bronchoconstrictor
response, activation of this cell population has not
been considered relevant to either the late phase inflammatory
cell influx within the airways following allergen bronchoprovocation
or to the mucosa! eosinophilia in chronic
clinical disease. As such, attention has focused on the T
lymphocyte as an orchestrator of these cellular events on
account of its ability to synthesize and release cytokines
relevant to the allergic process. It is now, however, realized
that many cell populations within the airways are able to
generate cytokines comparable with and complimentary to
those produced by T lymphocytes and that asthma cannot be
considered an inflammatory airway disorder dependent
upon activation of one single cell population. This review
details the current evidence that airway mast cells synthesize,
store and release cytokines relevant to allergic inflammation
and considers their potential involvement not only
in the cellular influx within the airways but also in the
fibrotic structural changes which are evident in chronic
disease. |
| format | Article |
| id | doaj-art-89cd111beb3a4f15b22675654db0e04d |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-89cd111beb3a4f15b22675654db0e04d2025-08-20T03:37:51ZengWileyCanadian Respiratory Journal1198-22411994-01-011211812710.1155/1994/435781Mast Cells, Cytokines and AsthmaAnthony E Redington0Peter H Howarth1Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UKFaculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UKThe appreciation that asthma is a chronic inflammatory disorder of the airways has led to a reappraisal of the importance of different cell populations within the bronchial mucosa with respect to their role in the regulation of the cellular events in this disease. While mast cell degranulation has been implicated in the acute allergic bronchoconstrictor response, activation of this cell population has not been considered relevant to either the late phase inflammatory cell influx within the airways following allergen bronchoprovocation or to the mucosa! eosinophilia in chronic clinical disease. As such, attention has focused on the T lymphocyte as an orchestrator of these cellular events on account of its ability to synthesize and release cytokines relevant to the allergic process. It is now, however, realized that many cell populations within the airways are able to generate cytokines comparable with and complimentary to those produced by T lymphocytes and that asthma cannot be considered an inflammatory airway disorder dependent upon activation of one single cell population. This review details the current evidence that airway mast cells synthesize, store and release cytokines relevant to allergic inflammation and considers their potential involvement not only in the cellular influx within the airways but also in the fibrotic structural changes which are evident in chronic disease.http://dx.doi.org/10.1155/1994/435781 |
| spellingShingle | Anthony E Redington Peter H Howarth Mast Cells, Cytokines and Asthma Canadian Respiratory Journal |
| title | Mast Cells, Cytokines and Asthma |
| title_full | Mast Cells, Cytokines and Asthma |
| title_fullStr | Mast Cells, Cytokines and Asthma |
| title_full_unstemmed | Mast Cells, Cytokines and Asthma |
| title_short | Mast Cells, Cytokines and Asthma |
| title_sort | mast cells cytokines and asthma |
| url | http://dx.doi.org/10.1155/1994/435781 |
| work_keys_str_mv | AT anthonyeredington mastcellscytokinesandasthma AT peterhhowarth mastcellscytokinesandasthma |