Inflammatory cytokines in newborn infants
Serum levels of IL-1β, IL-6 and TNF-α were measured in 48 healthy, termed neonates on the 1st (N1), 5th (N5) and 40th (N40) day after birth, compared with those in maternal serum (MS), umbilical cord (UC) and adult controls. Cytokine values in N1 and N5 were significantly elevated, than those in UC...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359890811 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555277832945664 |
|---|---|
| author | A. Sarandakou G. Giannaki A. Malamitsi-Puchner D. Rizos E. Hourdaki E. Protonotariou I. Phocas |
| author_facet | A. Sarandakou G. Giannaki A. Malamitsi-Puchner D. Rizos E. Hourdaki E. Protonotariou I. Phocas |
| author_sort | A. Sarandakou |
| collection | DOAJ |
| description | Serum levels of IL-1β, IL-6 and TNF-α were measured in 48 healthy, termed neonates on the 1st (N1), 5th (N5) and 40th (N40) day after birth, compared with those in maternal serum (MS), umbilical cord (UC) and adult controls. Cytokine values in N1 and N5 were significantly elevated, than those in UC and in controls (p<0.0001). IL-1β and IL-6 declined significantly from N1 to N40 (p<0.0001), while TNF-α increased significantly from N1 to N5 and declined thereafter. MS ∞ IL-1β and IL-6, but not MS ∞ TNF-α, were significantly higher than those of controls (p<0.0001). IL-1β values depended on the mode of delivery. In conclusion, the increased concentrations of IL-1 β, IL-6 and TNF-α during the perinatal period might suggest their involvement in an inflammation like process during normal parturition, and reflect also a newborn immune response to the stress of delivery and environmental changes. |
| format | Article |
| id | doaj-art-89c89222284e436c86ebed73008790ed |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-89c89222284e436c86ebed73008790ed2025-02-03T05:48:39ZengWileyMediators of Inflammation0962-93511466-18611998-01-017530931210.1080/09629359890811Inflammatory cytokines in newborn infantsA. Sarandakou0G. Giannaki1A. Malamitsi-Puchner2D. Rizos3E. Hourdaki4E. Protonotariou5I. Phocas6Hormonological Laboratory and Neonatal Unit, 2nd Department of Obstetrics and Gynaecology, ‘Areteion’ University Hospital, Athens, GreeceHormonological Laboratory and Neonatal Unit, 2nd Department of Obstetrics and Gynaecology, ‘Areteion’ University Hospital, Athens, GreeceHormonological Laboratory and Neonatal Unit, 2nd Department of Obstetrics and Gynaecology, ‘Areteion’ University Hospital, Athens, GreeceHormonological Laboratory and Neonatal Unit, 2nd Department of Obstetrics and Gynaecology, ‘Areteion’ University Hospital, Athens, GreeceHormonological Laboratory and Neonatal Unit, 2nd Department of Obstetrics and Gynaecology, ‘Areteion’ University Hospital, Athens, GreeceHormonological Laboratory and Neonatal Unit, 2nd Department of Obstetrics and Gynaecology, ‘Areteion’ University Hospital, Athens, GreeceHormonological Laboratory and Neonatal Unit, 2nd Department of Obstetrics and Gynaecology, ‘Areteion’ University Hospital, Athens, GreeceSerum levels of IL-1β, IL-6 and TNF-α were measured in 48 healthy, termed neonates on the 1st (N1), 5th (N5) and 40th (N40) day after birth, compared with those in maternal serum (MS), umbilical cord (UC) and adult controls. Cytokine values in N1 and N5 were significantly elevated, than those in UC and in controls (p<0.0001). IL-1β and IL-6 declined significantly from N1 to N40 (p<0.0001), while TNF-α increased significantly from N1 to N5 and declined thereafter. MS ∞ IL-1β and IL-6, but not MS ∞ TNF-α, were significantly higher than those of controls (p<0.0001). IL-1β values depended on the mode of delivery. In conclusion, the increased concentrations of IL-1 β, IL-6 and TNF-α during the perinatal period might suggest their involvement in an inflammation like process during normal parturition, and reflect also a newborn immune response to the stress of delivery and environmental changes.http://dx.doi.org/10.1080/09629359890811 |
| spellingShingle | A. Sarandakou G. Giannaki A. Malamitsi-Puchner D. Rizos E. Hourdaki E. Protonotariou I. Phocas Inflammatory cytokines in newborn infants Mediators of Inflammation |
| title | Inflammatory cytokines in newborn infants |
| title_full | Inflammatory cytokines in newborn infants |
| title_fullStr | Inflammatory cytokines in newborn infants |
| title_full_unstemmed | Inflammatory cytokines in newborn infants |
| title_short | Inflammatory cytokines in newborn infants |
| title_sort | inflammatory cytokines in newborn infants |
| url | http://dx.doi.org/10.1080/09629359890811 |
| work_keys_str_mv | AT asarandakou inflammatorycytokinesinnewborninfants AT ggiannaki inflammatorycytokinesinnewborninfants AT amalamitsipuchner inflammatorycytokinesinnewborninfants AT drizos inflammatorycytokinesinnewborninfants AT ehourdaki inflammatorycytokinesinnewborninfants AT eprotonotariou inflammatorycytokinesinnewborninfants AT iphocas inflammatorycytokinesinnewborninfants |