The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection.
Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important role in adaptive immunity to both Nippostrongylus brasiliensis and Salmonella enterica serovar Typh...
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| Main Authors: | Matthew Darby, Corinna Schnoeller, Alykhan Vira, Fiona Jane Culley, Saeeda Bobat, Erin Logan, Frank Kirstein, Jürgen Wess, Adam F Cunningham, Frank Brombacher, Murray E Selkirk, William G C Horsnell |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1004636 |
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