Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature review
ABSTRACT Agents that inhibit programmed cell death (IPD-1) in T lymphocytes are indicated for patients with advanced cancer. However, some individuals may develop endocrinological conditions, such as diabetes, thyroid dysfunction, and lipodystrophy, after treatment. This systematic review and case r...
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2024-11-01
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100509&lng=en&tlng=en |
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| _version_ | 1850251108752031744 |
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| author | Henri Friedhofer Cristina Pires Camargo Leandro Hirokazu Oshiro Daniel de Almeida Rocha Valente Rolf Gemperli |
| author_facet | Henri Friedhofer Cristina Pires Camargo Leandro Hirokazu Oshiro Daniel de Almeida Rocha Valente Rolf Gemperli |
| author_sort | Henri Friedhofer |
| collection | DOAJ |
| description | ABSTRACT Agents that inhibit programmed cell death (IPD-1) in T lymphocytes are indicated for patients with advanced cancer. However, some individuals may develop endocrinological conditions, such as diabetes, thyroid dysfunction, and lipodystrophy, after treatment. This systematic review and case report of IPD-1 lipodystrophies describes a patient who received nivolumab treatment for advanced clear cell renal carcinoma and subsequently developed diabetes as well as facial and body lipodystrophy. The patient complained of social distress due to her facial appearance. We treated the facial lipodystrophy with autologous fat grafting, which proved to be effective for more than three years. This study showed the efficacy of IPD-1 lipodystrophy treatment with long-term follow-up. |
| format | Article |
| id | doaj-art-89becc564d364f03aef08f915be361bb |
| institution | OA Journals |
| issn | 2317-6385 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj-art-89becc564d364f03aef08f915be361bb2025-08-20T01:57:59ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852024-11-012210.31744/einstein_journal/2024rc1111Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature reviewHenri Friedhoferhttps://orcid.org/0000-0002-3467-2222Cristina Pires Camargohttps://orcid.org/0000-0002-3134-0003Leandro Hirokazu Oshirohttps://orcid.org/0009-0005-8489-4228Daniel de Almeida Rocha Valentehttps://orcid.org/0000-0003-0310-7084Rolf Gemperlihttps://orcid.org/0000-0002-4147-4478ABSTRACT Agents that inhibit programmed cell death (IPD-1) in T lymphocytes are indicated for patients with advanced cancer. However, some individuals may develop endocrinological conditions, such as diabetes, thyroid dysfunction, and lipodystrophy, after treatment. This systematic review and case report of IPD-1 lipodystrophies describes a patient who received nivolumab treatment for advanced clear cell renal carcinoma and subsequently developed diabetes as well as facial and body lipodystrophy. The patient complained of social distress due to her facial appearance. We treated the facial lipodystrophy with autologous fat grafting, which proved to be effective for more than three years. This study showed the efficacy of IPD-1 lipodystrophy treatment with long-term follow-up.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100509&lng=en&tlng=enCarcinomarenal cellNivolumabThyroid glandT-LymphocytesDiabetes mellitusLipodystrophyAdipose tissueApoptosis |
| spellingShingle | Henri Friedhofer Cristina Pires Camargo Leandro Hirokazu Oshiro Daniel de Almeida Rocha Valente Rolf Gemperli Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature review Einstein (São Paulo) Carcinoma renal cell Nivolumab Thyroid gland T-Lymphocytes Diabetes mellitus Lipodystrophy Adipose tissue Apoptosis |
| title | Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature review |
| title_full | Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature review |
| title_fullStr | Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature review |
| title_full_unstemmed | Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature review |
| title_short | Treatment of facial lipodystrophy induced by a biologic agent (IPD-1): a literature review |
| title_sort | treatment of facial lipodystrophy induced by a biologic agent ipd 1 a literature review |
| topic | Carcinoma renal cell Nivolumab Thyroid gland T-Lymphocytes Diabetes mellitus Lipodystrophy Adipose tissue Apoptosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100509&lng=en&tlng=en |
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