Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents
Background: Sex hormones have a key impact on the development of the human body during puberty, including a significant influence on bone development - their shape, structure, length, and mineral density. Due to the growing number of transgender and gender diverse (TGD) adolescents and the increasi...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57200 |
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| author | Marta Chuncia Witold Czyż Julia Kacperczyk Filip Arczewski Karol Dziedzic Julia Kulbacka Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka |
| author_facet | Marta Chuncia Witold Czyż Julia Kacperczyk Filip Arczewski Karol Dziedzic Julia Kulbacka Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka |
| author_sort | Marta Chuncia |
| collection | DOAJ |
| description |
Background: Sex hormones have a key impact on the development of the human body during puberty, including a significant influence on bone development - their shape, structure, length, and mineral density. Due to the growing number of transgender and gender diverse (TGD) adolescents and the increasing demand for gender-affirming hormone therapy (GAHT), there is rising curiosity about the impact of this therapy on the developing body of a young person.
Purpose: This review aims to summarize the latest scientific reports on the impact of gonadotropin-releasing hormone analogues (GnRHas) and GAHT on the bone mineral density (BMD) of transgender adolescents undergoing gender-changing therapies.
Findings: Low pretreatment BMD is more common among TGD adolescents than in the general population, and this is more prevalent in transgirls than in transboys. BMD Z-scores decline during treatment with GnRHas and respond differentially to GAHT. Regular follow-up and health advice are essential. Further long-term studies of the effects of these therapies on peak bone mass and future fracture risk are needed.
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| format | Article |
| id | doaj-art-89bd12dc4303491cb7c9cc2e952eb4a8 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-89bd12dc4303491cb7c9cc2e952eb4a82025-01-07T08:22:59ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57200Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender AdolescentsMarta Chuncia0https://orcid.org/0009-0000-0913-9752Witold Czyż1https://orcid.org/0009-0006-4442-9900Julia Kacperczyk2https://orcid.org/0009-0007-6354-301XFilip Arczewski3https://orcid.org/0009-0008-5179-7255Karol Dziedzic4https://orcid.org/0009-0007-8317-723XJulia Kulbacka5https://orcid.org/0009-0005-1181-9104Maciej Wojszczyk6https://orcid.org/0009-0002-8668-8821Damian Zys7https://orcid.org/0009-0003-6578-6710Piotr Pasek8https://orcid.org/0009-0001-6218-9887Julia Ryniecka9https://orcid.org/0009-0000-5937-9498Central Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandMedical University of Lodz, Al. T. Kosciuszki 4, 90–419 Lodz, PolandMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, PolandUniversity Clinical Hospital No. 1 of the Medical University of Lodz, ul. Kopcińskiego 22, 90-153 Lodz, PolandUniversity Clinical Hospital No. 1 of the Medical University of Lodz, ul. Kopcińskiego 22, 90-153 Lodz, PolandCopernicus Memorial Hospital, ul. Pabianicka 62, 93-513 Lodz, PolandMedical University of Lodz, Al T .Kosciuszki 4, 90-419 Lodz, Poland Background: Sex hormones have a key impact on the development of the human body during puberty, including a significant influence on bone development - their shape, structure, length, and mineral density. Due to the growing number of transgender and gender diverse (TGD) adolescents and the increasing demand for gender-affirming hormone therapy (GAHT), there is rising curiosity about the impact of this therapy on the developing body of a young person. Purpose: This review aims to summarize the latest scientific reports on the impact of gonadotropin-releasing hormone analogues (GnRHas) and GAHT on the bone mineral density (BMD) of transgender adolescents undergoing gender-changing therapies. Findings: Low pretreatment BMD is more common among TGD adolescents than in the general population, and this is more prevalent in transgirls than in transboys. BMD Z-scores decline during treatment with GnRHas and respond differentially to GAHT. Regular follow-up and health advice are essential. Further long-term studies of the effects of these therapies on peak bone mass and future fracture risk are needed. https://apcz.umk.pl/QS/article/view/57200transgender and gender diverse youthpuberty suppressiongonadotropin-releasing hormone analoguegender-affirming hormone therapybone healthtransgender and bone |
| spellingShingle | Marta Chuncia Witold Czyż Julia Kacperczyk Filip Arczewski Karol Dziedzic Julia Kulbacka Maciej Wojszczyk Damian Zys Piotr Pasek Julia Ryniecka Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents Quality in Sport transgender and gender diverse youth puberty suppression gonadotropin-releasing hormone analogue gender-affirming hormone therapy bone health transgender and bone |
| title | Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents |
| title_full | Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents |
| title_fullStr | Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents |
| title_full_unstemmed | Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents |
| title_short | Impact of Gonadotropin-releasing Hormone Analogue and Gender-affirming Hormone Therapy on Bone Mineral Density in Transgender Adolescents |
| title_sort | impact of gonadotropin releasing hormone analogue and gender affirming hormone therapy on bone mineral density in transgender adolescents |
| topic | transgender and gender diverse youth puberty suppression gonadotropin-releasing hormone analogue gender-affirming hormone therapy bone health transgender and bone |
| url | https://apcz.umk.pl/QS/article/view/57200 |
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