Identification of two biological subgroups of complex regional pain syndrome type 1 by transcriptomic profiling of skin and blood in women

Identification of two biological subgroups of complex regional pain syndrome type 1 by transcriptomic profiling of skin and blood in women

Abstract Background Patients with Complex Regional Pain Syndrome (CRPS) present prolonged, debilitating pain and functional impairment. Treatments are not disease-modifying due to the poorly understood underlying pathomechanisms. This study aimed to identify the molecular signatures of potential CRP...

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Main Authors: Melina Pérez Vertti Valdés, Astrid Jüngel, Pamela Bitterli, Jan Devan, Hubert Rehrauer, Lennart Opitz, Laura Sirucek, Petra Schweinhardt, Sabrina Catanzaro, Oliver Distler, Florian Brunner, Stefan Dudli
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
Complex regional pain syndrome (CRPS)
RNA-seq
Peripheral blood mononuclear cells (PBMCs)
Cytokine quantification
Chronic pain
Online Access:https://doi.org/10.1186/s10020-025-01148-y
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