Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review
<i>Purpose</i>: To study the coexistence of ulcerative colitis (UC) and primary biliary cholangitis (PBC). <i>Methods</i>: The Beijing Friendship Hospital patient database was explored to identify patients presenting both UC and PBC from January 2015 to July 2024. By a review...
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MDPI AG
2024-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/61/1/44 |
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| author | Qi Li Ye Zong |
| author_facet | Qi Li Ye Zong |
| author_sort | Qi Li |
| collection | DOAJ |
| description | <i>Purpose</i>: To study the coexistence of ulcerative colitis (UC) and primary biliary cholangitis (PBC). <i>Methods</i>: The Beijing Friendship Hospital patient database was explored to identify patients presenting both UC and PBC from January 2015 to July 2024. By a review of the literature, the characteristics of UC patients who experienced PBC was summarized. <i>Results</i>: We identified 890 UC patients and reported 4 individuals who suffered from UC and PBC. Compared to the general population, UC patients seem to have a higher risk of PBC. Only 28 cases of UC with PBC have been reported so far. Most patients were diagnosed with UC prior to PBC. Once UC patients are complicated with PBC, they might experience more than one extraintestinal manifestation (EIM). Shared susceptibility genes, certain bacterial infections, and common immune-mediated mechanisms may be involved in the pathogenesis of UC patients with PBC. <i>Conclusions</i>: Although the coexistence of UC and PBC is uncommon, PBC should be considered in UC patients with hepatobiliary disorders. |
| format | Article |
| id | doaj-art-89babcd650494255be597913d149fe70 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-89babcd650494255be597913d149fe702025-01-24T13:40:21ZengMDPI AGMedicina1010-660X1648-91442024-12-016114410.3390/medicina61010044Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature ReviewQi Li0Ye Zong1National Clinical Research Center for Digestive Diseases, State Key Laboratory for Digestive Health, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaNational Clinical Research Center for Digestive Diseases, State Key Laboratory for Digestive Health, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China<i>Purpose</i>: To study the coexistence of ulcerative colitis (UC) and primary biliary cholangitis (PBC). <i>Methods</i>: The Beijing Friendship Hospital patient database was explored to identify patients presenting both UC and PBC from January 2015 to July 2024. By a review of the literature, the characteristics of UC patients who experienced PBC was summarized. <i>Results</i>: We identified 890 UC patients and reported 4 individuals who suffered from UC and PBC. Compared to the general population, UC patients seem to have a higher risk of PBC. Only 28 cases of UC with PBC have been reported so far. Most patients were diagnosed with UC prior to PBC. Once UC patients are complicated with PBC, they might experience more than one extraintestinal manifestation (EIM). Shared susceptibility genes, certain bacterial infections, and common immune-mediated mechanisms may be involved in the pathogenesis of UC patients with PBC. <i>Conclusions</i>: Although the coexistence of UC and PBC is uncommon, PBC should be considered in UC patients with hepatobiliary disorders.https://www.mdpi.com/1648-9144/61/1/44ulcerative colitisprimary biliary cholangitisextraintestinal manifestationsliver biopsy |
| spellingShingle | Qi Li Ye Zong Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review Medicina ulcerative colitis primary biliary cholangitis extraintestinal manifestations liver biopsy |
| title | Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review |
| title_full | Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review |
| title_fullStr | Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review |
| title_full_unstemmed | Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review |
| title_short | Primary Biliary Cholangitis Associated with Ulcerative Colitis: Case Series and Literature Review |
| title_sort | primary biliary cholangitis associated with ulcerative colitis case series and literature review |
| topic | ulcerative colitis primary biliary cholangitis extraintestinal manifestations liver biopsy |
| url | https://www.mdpi.com/1648-9144/61/1/44 |
| work_keys_str_mv | AT qili primarybiliarycholangitisassociatedwithulcerativecolitiscaseseriesandliteraturereview AT yezong primarybiliarycholangitisassociatedwithulcerativecolitiscaseseriesandliteraturereview |