Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols

In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an...

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Main Authors: Roberta Novaes Reis Corrales, Liliane Sena Pinheiro, Elaine Soares Coimbra, Adilson David Da Silva, Mireille Le Hyaric
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2010.106
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author Roberta Novaes Reis Corrales
Liliane Sena Pinheiro
Elaine Soares Coimbra
Adilson David Da Silva
Mireille Le Hyaric
author_facet Roberta Novaes Reis Corrales
Liliane Sena Pinheiro
Elaine Soares Coimbra
Adilson David Da Silva
Mireille Le Hyaric
author_sort Roberta Novaes Reis Corrales
collection DOAJ
description In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an aliphatic moiety with eight to 12 carbon atoms displayed a good activity against L. amazonensis and L. major, and two of them also showed antiproliferative activity against L. chagasi. The best results were obtained for the N-dodecanoyl ethylenediamine derivative and for N-decyl aminoalcohol (IC50 = 5.2 and 0.7 μM, respectively).
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institution Kabale University
issn 1537-744X
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publishDate 2010-01-01
publisher Wiley
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series The Scientific World Journal
spelling doaj-art-89b8450b115541f4909181a620890ded2025-02-03T07:24:49ZengWileyThe Scientific World Journal1537-744X2010-01-01101067107210.1100/tsw.2010.106Synthesis and Antileishmanial Activity of Lipophilic Aromatic AminoalcoholsRoberta Novaes Reis Corrales0Liliane Sena Pinheiro1Elaine Soares Coimbra2Adilson David Da Silva3Mireille Le Hyaric4Departamento de Química, Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Parasitologia, Microbiologia e Imunologia Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Parasitologia, Microbiologia e Imunologia Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Química, Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Química, Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilIn this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an aliphatic moiety with eight to 12 carbon atoms displayed a good activity against L. amazonensis and L. major, and two of them also showed antiproliferative activity against L. chagasi. The best results were obtained for the N-dodecanoyl ethylenediamine derivative and for N-decyl aminoalcohol (IC50 = 5.2 and 0.7 μM, respectively).http://dx.doi.org/10.1100/tsw.2010.106
spellingShingle Roberta Novaes Reis Corrales
Liliane Sena Pinheiro
Elaine Soares Coimbra
Adilson David Da Silva
Mireille Le Hyaric
Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
The Scientific World Journal
title Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
title_full Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
title_fullStr Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
title_full_unstemmed Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
title_short Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
title_sort synthesis and antileishmanial activity of lipophilic aromatic aminoalcohols
url http://dx.doi.org/10.1100/tsw.2010.106
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