Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an...
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Format: | Article |
Language: | English |
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Wiley
2010-01-01
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Series: | The Scientific World Journal |
Online Access: | http://dx.doi.org/10.1100/tsw.2010.106 |
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author | Roberta Novaes Reis Corrales Liliane Sena Pinheiro Elaine Soares Coimbra Adilson David Da Silva Mireille Le Hyaric |
author_facet | Roberta Novaes Reis Corrales Liliane Sena Pinheiro Elaine Soares Coimbra Adilson David Da Silva Mireille Le Hyaric |
author_sort | Roberta Novaes Reis Corrales |
collection | DOAJ |
description | In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an aliphatic moiety with eight to 12 carbon atoms displayed a good activity against L. amazonensis and L. major, and two of them also showed antiproliferative activity against L. chagasi. The best results were obtained for the N-dodecanoyl ethylenediamine derivative and for N-decyl aminoalcohol (IC50 = 5.2 and 0.7 μM, respectively). |
format | Article |
id | doaj-art-89b8450b115541f4909181a620890ded |
institution | Kabale University |
issn | 1537-744X |
language | English |
publishDate | 2010-01-01 |
publisher | Wiley |
record_format | Article |
series | The Scientific World Journal |
spelling | doaj-art-89b8450b115541f4909181a620890ded2025-02-03T07:24:49ZengWileyThe Scientific World Journal1537-744X2010-01-01101067107210.1100/tsw.2010.106Synthesis and Antileishmanial Activity of Lipophilic Aromatic AminoalcoholsRoberta Novaes Reis Corrales0Liliane Sena Pinheiro1Elaine Soares Coimbra2Adilson David Da Silva3Mireille Le Hyaric4Departamento de Química, Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Parasitologia, Microbiologia e Imunologia Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Parasitologia, Microbiologia e Imunologia Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Química, Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilDepartamento de Química, Universidade Federal de Juiz de Fora Campus Universitário, Juiz de Fora, Minas Gerais, BrazilIn this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an aliphatic moiety with eight to 12 carbon atoms displayed a good activity against L. amazonensis and L. major, and two of them also showed antiproliferative activity against L. chagasi. The best results were obtained for the N-dodecanoyl ethylenediamine derivative and for N-decyl aminoalcohol (IC50 = 5.2 and 0.7 μM, respectively).http://dx.doi.org/10.1100/tsw.2010.106 |
spellingShingle | Roberta Novaes Reis Corrales Liliane Sena Pinheiro Elaine Soares Coimbra Adilson David Da Silva Mireille Le Hyaric Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols The Scientific World Journal |
title | Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols |
title_full | Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols |
title_fullStr | Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols |
title_full_unstemmed | Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols |
title_short | Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols |
title_sort | synthesis and antileishmanial activity of lipophilic aromatic aminoalcohols |
url | http://dx.doi.org/10.1100/tsw.2010.106 |
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