The self-renewal signaling pathways utilized by gastric cancer stem cells
Gastric cancer is a leading cause of cancer-related mortality worldwide. Cancer stem cells are the source of tumor recurrence and metastasis. Self-renewal is a marker of cancer stem cells and also the basis of long-lasting survival and tumor progression. Although the mechanism of gastric cancer stem...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317697577 |
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| _version_ | 1850055074224537600 |
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| author | Ying Fu Hui Li Xishan Hao |
| author_facet | Ying Fu Hui Li Xishan Hao |
| author_sort | Ying Fu |
| collection | DOAJ |
| description | Gastric cancer is a leading cause of cancer-related mortality worldwide. Cancer stem cells are the source of tumor recurrence and metastasis. Self-renewal is a marker of cancer stem cells and also the basis of long-lasting survival and tumor progression. Although the mechanism of gastric cancer stem cell self-renewal is not clear, there are several signaling pathways and environmental factors known to be involved. This mini review describes recent developments in the self-renewal signaling pathway of gastric cancer stem cell research. Advancements made in this field of research will likely support the development of novel therapeutic strategies for gastric cancer. |
| format | Article |
| id | doaj-art-89afc9c6d5c24c8a931be0c3dd9718af |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-89afc9c6d5c24c8a931be0c3dd9718af2025-08-20T02:52:05ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317697577The self-renewal signaling pathways utilized by gastric cancer stem cellsYing FuHui LiXishan HaoGastric cancer is a leading cause of cancer-related mortality worldwide. Cancer stem cells are the source of tumor recurrence and metastasis. Self-renewal is a marker of cancer stem cells and also the basis of long-lasting survival and tumor progression. Although the mechanism of gastric cancer stem cell self-renewal is not clear, there are several signaling pathways and environmental factors known to be involved. This mini review describes recent developments in the self-renewal signaling pathway of gastric cancer stem cell research. Advancements made in this field of research will likely support the development of novel therapeutic strategies for gastric cancer.https://doi.org/10.1177/1010428317697577 |
| spellingShingle | Ying Fu Hui Li Xishan Hao The self-renewal signaling pathways utilized by gastric cancer stem cells Tumor Biology |
| title | The self-renewal signaling pathways utilized by gastric cancer stem cells |
| title_full | The self-renewal signaling pathways utilized by gastric cancer stem cells |
| title_fullStr | The self-renewal signaling pathways utilized by gastric cancer stem cells |
| title_full_unstemmed | The self-renewal signaling pathways utilized by gastric cancer stem cells |
| title_short | The self-renewal signaling pathways utilized by gastric cancer stem cells |
| title_sort | self renewal signaling pathways utilized by gastric cancer stem cells |
| url | https://doi.org/10.1177/1010428317697577 |
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