Retinal thickness is indicative of visual loss in patients with occipital lobe infarction

Retinal thickness is indicative of visual loss in patients with occipital lobe infarction

PurposeWe explored the relationship between retinal thicknesses and vessels using optical coherence tomography angiography (OCT)/ OCT angiography (OCTA) and clinical outcomes in occipital lobe infarction (OI).MethodsA total of 52 OI patients and 105 controls underwent macular OCT/OCTA scans covering...

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Main Authors: Xueling Bai, Le Cao, Hang Wang, William Robert Kwapong, Yuying Yan, Guina Liu, Junfeng Liu, Fayun Hu, Bo Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Neurology
Subjects:
occipital lobe infarction
vision
retinal vessels
retinal structural thickness
infarct diameter
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1546439/full
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Summary:PurposeWe explored the relationship between retinal thicknesses and vessels using optical coherence tomography angiography (OCT)/ OCT angiography (OCTA) and clinical outcomes in occipital lobe infarction (OI).MethodsA total of 52 OI patients and 105 controls underwent macular OCT/OCTA scans covering a 6 × 6 mm2 area around the fovea. The retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), superficial vascular complex (SVC), and deep vascular complex (DVC) were measured using the OCT/OCTA tool. All participants underwent a visual acuity examination.ResultsOI patients showed reduced GCIPL thickness and lower SVC density but higher DVC density (all p < 0.001) compared to the controls, both in the whole area and across the four sectors. Eyes ipsilateral or contralateral to infarction showed reduced GCIPL thickness and lower SVC density (all p < 0.05). The GCIPL thickness was significantly correlated with the infarct diameter and visual acuity (both p < 0.05), while the SVC density was also significantly correlated with the infarct diameter (p = 0.002). The visual acuity showed a significant association with the infarct diameter (p < 0.001), and the reduction of the GCIPL partially mediated this effect (a proportion of the mediated effect at 15.17%, p = 0.028).ConclusionGCIPL thinning may account for the effect of infarct diameter on visual acuity in OI patients. Future prospective studies are needed to assess OCT/OCTA as a potential marker of visual loss in OI.
ISSN:1664-2295

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