The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study
Abstract Background This study aimed to investigate the potential relationship between the newly defined adiposity metric, the Body Roundness Index (BRI), which assesses central obesity, and the development of new-onset hyperuricemia. Methods In the Kailuan cohort study from 2006 to 2019, 91,804 eli...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-025-21440-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585296852549632 |
|---|---|
| author | Xi Cai Naihui Zhao Xuemei Yang Jiajia Ma Yajing Liang Yicheng Liao Ruiyue Liu Xinran Wen Shuohua Chen Guodong Wang Na Li Shouling Wu Liufu Cui |
| author_facet | Xi Cai Naihui Zhao Xuemei Yang Jiajia Ma Yajing Liang Yicheng Liao Ruiyue Liu Xinran Wen Shuohua Chen Guodong Wang Na Li Shouling Wu Liufu Cui |
| author_sort | Xi Cai |
| collection | DOAJ |
| description | Abstract Background This study aimed to investigate the potential relationship between the newly defined adiposity metric, the Body Roundness Index (BRI), which assesses central obesity, and the development of new-onset hyperuricemia. Methods In the Kailuan cohort study from 2006 to 2019, 91,804 eligible participants were included. A multivariate Cox regression model was used to test the correlation between BRI and hyperuricemia. At the same time, the restricted cubic spline was applied to solve the dose-response relationship between BRI and the risk of hyperuricemia.Then, stratified analysis was carried out using multivariate Cox regression according to age, sex, hs-CRP level, TG level, education level, smoking status and hypertension status. Results The results showed that the risk of new-onset hyperuricemia was significantly increased in the highest quartile compared with the lowest quartile. After adjusting for confounders, compared with Q1, the HR (95% CI) for new-onset hyperuricemia was 1.24 (1.18–1.30), 1.32 (1.25–1.40), and 1.40 (1.29–1.52) for Q2, Q3, and Q4, respectively. Restricted cubic spline analysis showed a J-curve relationship between baseline BRI levels and new-onset hyperuricaemia. Age, sex, hs-CRP level, TG level, income level, education level, smoking, and hypertension each had a multiplicative interaction with BRI at baseline. Conclusion We found that elevated BRI increased the risk of developing new-onset hyperuricaemia. In addition, the association between elevated BRI and the risk of new-onset hyperuricemia showed dependency on age, sex, hs-CRP level, TG level, education level, smoking status and hypertension status. |
| format | Article |
| id | doaj-art-89ac39114e354c1f9b86021b8be15c61 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-89ac39114e354c1f9b86021b8be15c612025-01-26T12:56:14ZengBMCBMC Public Health1471-24582025-01-012511910.1186/s12889-025-21440-0The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort studyXi Cai0Naihui Zhao1Xuemei Yang2Jiajia Ma3Yajing Liang4Yicheng Liao5Ruiyue Liu6Xinran Wen7Shuohua Chen8Guodong Wang9Na Li10Shouling Wu11Liufu Cui12Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and TechnologySchool of Public Health, North China University of Science and TechnologyDepartment of Cardiology, First Affiliated Hospital of Kunming Medical UniversityDepartment of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Cardiology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Cardiology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Cardiology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Cardiology, Kailuan General Hospital, North China University of Science and TechnologyDepartment of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and TechnologyAbstract Background This study aimed to investigate the potential relationship between the newly defined adiposity metric, the Body Roundness Index (BRI), which assesses central obesity, and the development of new-onset hyperuricemia. Methods In the Kailuan cohort study from 2006 to 2019, 91,804 eligible participants were included. A multivariate Cox regression model was used to test the correlation between BRI and hyperuricemia. At the same time, the restricted cubic spline was applied to solve the dose-response relationship between BRI and the risk of hyperuricemia.Then, stratified analysis was carried out using multivariate Cox regression according to age, sex, hs-CRP level, TG level, education level, smoking status and hypertension status. Results The results showed that the risk of new-onset hyperuricemia was significantly increased in the highest quartile compared with the lowest quartile. After adjusting for confounders, compared with Q1, the HR (95% CI) for new-onset hyperuricemia was 1.24 (1.18–1.30), 1.32 (1.25–1.40), and 1.40 (1.29–1.52) for Q2, Q3, and Q4, respectively. Restricted cubic spline analysis showed a J-curve relationship between baseline BRI levels and new-onset hyperuricaemia. Age, sex, hs-CRP level, TG level, income level, education level, smoking, and hypertension each had a multiplicative interaction with BRI at baseline. Conclusion We found that elevated BRI increased the risk of developing new-onset hyperuricaemia. In addition, the association between elevated BRI and the risk of new-onset hyperuricemia showed dependency on age, sex, hs-CRP level, TG level, education level, smoking status and hypertension status.https://doi.org/10.1186/s12889-025-21440-0Body roundness indexObesityHyperuricemia |
| spellingShingle | Xi Cai Naihui Zhao Xuemei Yang Jiajia Ma Yajing Liang Yicheng Liao Ruiyue Liu Xinran Wen Shuohua Chen Guodong Wang Na Li Shouling Wu Liufu Cui The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study BMC Public Health Body roundness index Obesity Hyperuricemia |
| title | The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study |
| title_full | The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study |
| title_fullStr | The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study |
| title_full_unstemmed | The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study |
| title_short | The association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study |
| title_sort | association between body roundness index and new onset hyperuricemia in chinese population the kailuan cohort study |
| topic | Body roundness index Obesity Hyperuricemia |
| url | https://doi.org/10.1186/s12889-025-21440-0 |
| work_keys_str_mv | AT xicai theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT naihuizhao theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT xuemeiyang theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT jiajiama theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT yajingliang theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT yichengliao theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT ruiyueliu theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT xinranwen theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT shuohuachen theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT guodongwang theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT nali theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT shoulingwu theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT liufucui theassociationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT xicai associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT naihuizhao associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT xuemeiyang associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT jiajiama associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT yajingliang associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT yichengliao associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT ruiyueliu associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT xinranwen associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT shuohuachen associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT guodongwang associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT nali associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT shoulingwu associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy AT liufucui associationbetweenbodyroundnessindexandnewonsethyperuricemiainchinesepopulationthekailuancohortstudy |