The selenoprotein P/ApoER2 axis facilitates selenium accumulation in selenoprotein P-accepting cells and confers prolonged resistance to ferroptosis

The selenoprotein P/ApoER2 axis facilitates selenium accumulation in selenoprotein P-accepting cells and confers prolonged resistance to ferroptosis

The essential trace element selenium (Se) plays a significant role in redox homeostasis, while Se is very reactive and has a potent toxicity. Understanding the molecular machinery that supports Se metabolism is important for the both physiological and pathophysiological context. Incorporated Se is t...

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Bibliographic Details
Main Authors: Atsuya Ichikawa, Takashi Toyama, Hiroki Taguchi, Satoru Shiina, Hayato Takashima, Kazuaki Takahashi, Yasumitsu Ogra, Ayako Mizuno, Kotoko Arisawa, Yoshiro Saito
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
Selenoprotein P
Apolipoprotein E receptor 2
Glutathione peroxidase
Selenium
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001776
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