Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis
Purpose Rheumatoid arthritis (RA) is an insidious autoimmune disease, with an immunological onset years before diagnosis. Early interventions in preclinical stages could prevent or minimise the progression towards irreversible joint damage. The SCREEN-RA cohort (Evaluation of a SCREENing strategy fo...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021-07-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/7/e048409.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850285244500934656 |
|---|---|
| author | Axel Finckh Kim Lauper Denis Mongin Delphine S Courvoisier Celine Lamacchia Diego Kyburz Andrea Rubbert-Roth Benoît Thomas P Gilbert Eric Trunk Olivia Studer Burkhard Moeller |
| author_facet | Axel Finckh Kim Lauper Denis Mongin Delphine S Courvoisier Celine Lamacchia Diego Kyburz Andrea Rubbert-Roth Benoît Thomas P Gilbert Eric Trunk Olivia Studer Burkhard Moeller |
| author_sort | Axel Finckh |
| collection | DOAJ |
| description | Purpose Rheumatoid arthritis (RA) is an insidious autoimmune disease, with an immunological onset years before diagnosis. Early interventions in preclinical stages could prevent or minimise the progression towards irreversible joint damage. The SCREEN-RA cohort (Evaluation of a SCREENing strategy for Rheumatoid Arthritis) aims to characterise the preclinical stages of the disease, to identify environmental risk factors, and to discover or validate novel biomarkers predictive for RA development.Participants SCREEN-RA includes an at-risk population for RA, namely first-degree relatives of patients with established RA.Findings to date The cohort started in 2009 is composed of mostly asymptomatic healthy individuals (total n=1458, 7262 person-years), with a mean age of 44 years at enrolment, 74% female and 91% Caucasian ethnicity. During the study period, 16 participants have developed RA. All participants provide baseline serum, DNA and RNA samples, and in a subset, stool samples and oral examination are performed for microbiota assessment. At enrolment, 10% of participants had asymptomatic autoimmunity associated with RA (n=147), 10% presented ‘clinically suspect arthralgias’ (n=143) and 3% reported arthralgias in conjunction with autoimmunity or high genetic risk (n=51). Studies with this cohort have uncovered risk factors for RA development, such as female hormonal factors, poor oral health or intestinal dysbiosis.Future plans Future directions include immunological and ‘multiomics’ approaches to discover new biological markers of progression towards RA, as well as testing preventive interventions in ‘high-risk’ population. |
| format | Article |
| id | doaj-art-89a5518401bd4e108fe623aae311986c |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-89a5518401bd4e108fe623aae311986c2025-08-20T01:47:21ZengBMJ Publishing GroupBMJ Open2044-60552021-07-0111710.1136/bmjopen-2020-048409Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritisAxel Finckh0Kim Lauper1Denis Mongin2Delphine S Courvoisier3Celine Lamacchia4Diego Kyburz5Andrea Rubbert-Roth6Benoît Thomas P Gilbert7Eric Trunk8Olivia Studer9Burkhard Moeller1010 Department of Rheumatology, Geneva University Hospitals, Geneve, SwitzerlandCentre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, EnglandDivision of Rheumatology, Geneva University Hospitals, Geneva, SwitzerlandDivision of Rheumatology, Department of Internal Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of Rheumatology, Geneva University Hospitals (HUG), Geneve, Switzerland7University Hospital, Basel, SwitzerlandDivision of Rheumatology, Cantonal Clinic St. Gallen, St. Gallen, SwitzerlandDivision of Rheumatology, Department of Internal Medicine, Geneva University Hospitals, Geneva, SwitzerlandDivision of Rheumatology, Geneva University Hospitals (HUG), Geneve, SwitzerlandUniversity Hospitals of Geneva, Geneva, SwitzerlandUniversity Hospital of Bern, Bern, SwitzerlandPurpose Rheumatoid arthritis (RA) is an insidious autoimmune disease, with an immunological onset years before diagnosis. Early interventions in preclinical stages could prevent or minimise the progression towards irreversible joint damage. The SCREEN-RA cohort (Evaluation of a SCREENing strategy for Rheumatoid Arthritis) aims to characterise the preclinical stages of the disease, to identify environmental risk factors, and to discover or validate novel biomarkers predictive for RA development.Participants SCREEN-RA includes an at-risk population for RA, namely first-degree relatives of patients with established RA.Findings to date The cohort started in 2009 is composed of mostly asymptomatic healthy individuals (total n=1458, 7262 person-years), with a mean age of 44 years at enrolment, 74% female and 91% Caucasian ethnicity. During the study period, 16 participants have developed RA. All participants provide baseline serum, DNA and RNA samples, and in a subset, stool samples and oral examination are performed for microbiota assessment. At enrolment, 10% of participants had asymptomatic autoimmunity associated with RA (n=147), 10% presented ‘clinically suspect arthralgias’ (n=143) and 3% reported arthralgias in conjunction with autoimmunity or high genetic risk (n=51). Studies with this cohort have uncovered risk factors for RA development, such as female hormonal factors, poor oral health or intestinal dysbiosis.Future plans Future directions include immunological and ‘multiomics’ approaches to discover new biological markers of progression towards RA, as well as testing preventive interventions in ‘high-risk’ population.https://bmjopen.bmj.com/content/11/7/e048409.full |
| spellingShingle | Axel Finckh Kim Lauper Denis Mongin Delphine S Courvoisier Celine Lamacchia Diego Kyburz Andrea Rubbert-Roth Benoît Thomas P Gilbert Eric Trunk Olivia Studer Burkhard Moeller Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis BMJ Open |
| title | Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis |
| title_full | Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis |
| title_fullStr | Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis |
| title_full_unstemmed | Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis |
| title_short | Cohort profile: SCREEN-RA: design, methods and perspectives of a Swiss cohort study of first-degree relatives of patients with rheumatoid arthritis |
| title_sort | cohort profile screen ra design methods and perspectives of a swiss cohort study of first degree relatives of patients with rheumatoid arthritis |
| url | https://bmjopen.bmj.com/content/11/7/e048409.full |
| work_keys_str_mv | AT axelfinckh cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT kimlauper cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT denismongin cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT delphinescourvoisier cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT celinelamacchia cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT diegokyburz cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT andrearubbertroth cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT benoitthomaspgilbert cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT erictrunk cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT oliviastuder cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis AT burkhardmoeller cohortprofilescreenradesignmethodsandperspectivesofaswisscohortstudyoffirstdegreerelativesofpatientswithrheumatoidarthritis |