Decoding serotonin: the molecular symphony behind depression
The serotonin (5-hydroxytryptamine) system represents a crucial neurotransmitter network that regulates mood, behavior, and cognitive functions, playing a significant role in the pathogenesis and progression of depression. Although this perspective faces significant challenges, the serotonin system...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1572462/full |
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| author | Yue Shu Lei Tian Xing Wang Tinyang Meng Shouyang Yu Yulan Li |
| author_facet | Yue Shu Lei Tian Xing Wang Tinyang Meng Shouyang Yu Yulan Li |
| author_sort | Yue Shu |
| collection | DOAJ |
| description | The serotonin (5-hydroxytryptamine) system represents a crucial neurotransmitter network that regulates mood, behavior, and cognitive functions, playing a significant role in the pathogenesis and progression of depression. Although this perspective faces significant challenges, the serotonin system continues to exert substantial modulatory effects on specific aspects of psychological functioning and actively contributes to multiple pathological processes in depression development. Therefore, this review systematically integrates interdisciplinary research advances regarding the relationship between the 5-hydroxytryptamine (5-HT) system and depression. By focusing on core biological processes including serotonin biosynthesis and metabolism, SERT gene regulatory networks, and protein molecular modifications, it aims to elucidate how 5-HT system dysregulation contributes to the development of depression, while providing novel research perspectives and therapeutic targets for innovative antidepressant drug development. |
| format | Article |
| id | doaj-art-899f72ef0909420ca68c12edd9cc5582 |
| institution | OA Journals |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-899f72ef0909420ca68c12edd9cc55822025-08-20T02:24:37ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-04-011910.3389/fncel.2025.15724621572462Decoding serotonin: the molecular symphony behind depressionYue Shu0Lei Tian1Xing Wang2Tinyang Meng3Shouyang Yu4Yulan Li5The First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaKey Laboratory of Brain Science, Key Laboratory of Anesthesia and Organ Protection of Ministry of Education (In Cultivation), Zunyi Medical University, Zunyi, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe serotonin (5-hydroxytryptamine) system represents a crucial neurotransmitter network that regulates mood, behavior, and cognitive functions, playing a significant role in the pathogenesis and progression of depression. Although this perspective faces significant challenges, the serotonin system continues to exert substantial modulatory effects on specific aspects of psychological functioning and actively contributes to multiple pathological processes in depression development. Therefore, this review systematically integrates interdisciplinary research advances regarding the relationship between the 5-hydroxytryptamine (5-HT) system and depression. By focusing on core biological processes including serotonin biosynthesis and metabolism, SERT gene regulatory networks, and protein molecular modifications, it aims to elucidate how 5-HT system dysregulation contributes to the development of depression, while providing novel research perspectives and therapeutic targets for innovative antidepressant drug development.https://www.frontiersin.org/articles/10.3389/fncel.2025.1572462/fulldepressionserotoninserotonin transportertryptophantryptophan hydroxylasevesicular monoamine transporter |
| spellingShingle | Yue Shu Lei Tian Xing Wang Tinyang Meng Shouyang Yu Yulan Li Decoding serotonin: the molecular symphony behind depression Frontiers in Cellular Neuroscience depression serotonin serotonin transporter tryptophan tryptophan hydroxylase vesicular monoamine transporter |
| title | Decoding serotonin: the molecular symphony behind depression |
| title_full | Decoding serotonin: the molecular symphony behind depression |
| title_fullStr | Decoding serotonin: the molecular symphony behind depression |
| title_full_unstemmed | Decoding serotonin: the molecular symphony behind depression |
| title_short | Decoding serotonin: the molecular symphony behind depression |
| title_sort | decoding serotonin the molecular symphony behind depression |
| topic | depression serotonin serotonin transporter tryptophan tryptophan hydroxylase vesicular monoamine transporter |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1572462/full |
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