Machine Learning-Assisted Drug Repurposing Framework for Discovery of Aurora Kinase B Inhibitors

Machine Learning-Assisted Drug Repurposing Framework for Discovery of Aurora Kinase B Inhibitors

<b>Background:</b> Aurora kinase B (AurB) is a pivotal regulator of mitosis, making it a compelling target for cancer therapy. Despite significant advances in protein kinase inhibitor development, there are currently no AurB inhibitors readily available for therapeutic use. <b>Meth...

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Bibliographic Details
Main Authors: George Nicolae Daniel Ion, George Mihai Nitulescu, Dragos Paul Mihai
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
AURKB
cancer therapy
protein kinase inhibition
virtual screening
computer-aided drug design and discovery
interaction fingerprints
Online Access:https://www.mdpi.com/1424-8247/18/1/13
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