Machine Learning-Assisted Drug Repurposing Framework for Discovery of Aurora Kinase B Inhibitors
<b>Background:</b> Aurora kinase B (AurB) is a pivotal regulator of mitosis, making it a compelling target for cancer therapy. Despite significant advances in protein kinase inhibitor development, there are currently no AurB inhibitors readily available for therapeutic use. <b>Meth...
Saved in:
Main Authors: | George Nicolae Daniel Ion, George Mihai Nitulescu, Dragos Paul Mihai |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-12-01
|
Series: | Pharmaceuticals |
Subjects: | |
Online Access: | https://www.mdpi.com/1424-8247/18/1/13 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trialsResearch in context
by: Yue Zhao, et al.
Published: (2025-02-01) -
Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer
by: Bohan Ning, et al.
Published: (2025-01-01) -
Expanding the therapeutic horizon in acute myeloid leukemia: The role of phosphoinositide-3-kinase-γ inhibition
by: Soumyajit Das, et al.
Published: (2024-12-01) -
Aurora kinase as a putative target to tick control
by: Bruno Moraes, et al.
Published: (2024-08-01) -
Small cell discovery based on TOA fingerprint database
by: Yang CHEN, et al.
Published: (2017-09-01)