The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population
The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. In this case-control study, 76 HFRS patients and 370 healthy controls of the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/308237 |
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| author | Ying Ma Bin Yuan Jing Yi Ran Zhuang Jiuping Wang Yun Zhang Zhuwei Xu Yusi Zhang Bei Liu Chao Wei Chunmei Zhang Angang Yang Boquan Jin |
| author_facet | Ying Ma Bin Yuan Jing Yi Ran Zhuang Jiuping Wang Yun Zhang Zhuwei Xu Yusi Zhang Bei Liu Chao Wei Chunmei Zhang Angang Yang Boquan Jin |
| author_sort | Ying Ma |
| collection | DOAJ |
| description | The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. In this case-control study, 76 HFRS patients and 370 healthy controls of the Chinese Han population were typed for the HLA-A, -B, and -DRB1 loci. The general variation at the HLA-DRB1 locus was associated with the onset of HFRS (P<0.05). The increasing frequencies of HLA-DRB1*09 and HLA-B*46-DRB1*09 in HFRS patients were observed as reproducing a previous study. Moreover, the HLA-B*51-DRB1*09 was susceptible to HFRS (P=0.037; OR =3.62; 95% CI: 1.00–13.18). The increasing frequencies of HLA-B*46, HLA-B*46-DRB1*09, and HLA-B*51-DRB1*09 were observed almost in severe/critical HFRS patients. The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P=0.011), HLA-B*51-DRB1*09 (P=0.041), or HLA-B*46 (P=0.011) positive patients than that in the negative patients. These findings suggest that the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury, which improve our understanding of the HLA polymorphism for a different outcome of HTNV infection. |
| format | Article |
| id | doaj-art-898d45cd83094d48aaeff770ed0118bc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-898d45cd83094d48aaeff770ed0118bc2025-08-20T03:38:01ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/308237308237The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han PopulationYing Ma0Bin Yuan1Jing Yi2Ran Zhuang3Jiuping Wang4Yun Zhang5Zhuwei Xu6Yusi Zhang7Bei Liu8Chao Wei9Chunmei Zhang10Angang Yang11Boquan Jin12Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Infectious Disease, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaDepartment of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, ChinaThe polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. In this case-control study, 76 HFRS patients and 370 healthy controls of the Chinese Han population were typed for the HLA-A, -B, and -DRB1 loci. The general variation at the HLA-DRB1 locus was associated with the onset of HFRS (P<0.05). The increasing frequencies of HLA-DRB1*09 and HLA-B*46-DRB1*09 in HFRS patients were observed as reproducing a previous study. Moreover, the HLA-B*51-DRB1*09 was susceptible to HFRS (P=0.037; OR =3.62; 95% CI: 1.00–13.18). The increasing frequencies of HLA-B*46, HLA-B*46-DRB1*09, and HLA-B*51-DRB1*09 were observed almost in severe/critical HFRS patients. The mean level of maximum serum creatinine was higher in HLA-B*46-DRB1*09 (P=0.011), HLA-B*51-DRB1*09 (P=0.041), or HLA-B*46 (P=0.011) positive patients than that in the negative patients. These findings suggest that the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury, which improve our understanding of the HLA polymorphism for a different outcome of HTNV infection.http://dx.doi.org/10.1155/2012/308237 |
| spellingShingle | Ying Ma Bin Yuan Jing Yi Ran Zhuang Jiuping Wang Yun Zhang Zhuwei Xu Yusi Zhang Bei Liu Chao Wei Chunmei Zhang Angang Yang Boquan Jin The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population Clinical and Developmental Immunology |
| title | The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population |
| title_full | The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population |
| title_fullStr | The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population |
| title_full_unstemmed | The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population |
| title_short | The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population |
| title_sort | genetic polymorphisms of hla are strongly correlated with the disease severity after hantaan virus infection in the chinese han population |
| url | http://dx.doi.org/10.1155/2012/308237 |
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